| + |
ERBB2 | up-regulates activity
phosphorylation
|
SHCBP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280009 |
Ser273 |
SSLSNCNsDSEQENI |
Homo sapiens |
|
| pmid |
sentence |
| 35013128 |
Blocking HER2 activation using trastuzumab effectively abolished EGF-induced nuclear localization of SHCBP1 in gastric cancer cells [7].|In addition, nuclear translocation of SHCBP1 is a downstream consequence of HER2 activation, which is dependent on phosphorylation of SHCBP1 at the Ser273 site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AURKB | up-regulates activity
phosphorylation
|
SHCBP1 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273552 |
Ser634 |
QIKKKRLsELGITQA |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 23704356 |
AurB phosphorylates Ser634 of SHCBP1 during mitosis. We generated a phosphorylation site mutant, S634A-SHCBP1, which was prematurely recruited to the central spindle during anaphase and inhibited furrowing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |