+ |
TET1 | up-regulates quantity by expression
transcriptional regulation
|
PTEN |
0.386 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259096 |
|
|
Homo sapiens |
|
pmid |
sentence |
27121319 |
We also found that TET1 directly binds to the promoter region of PTEN and activates its transcription through demethylation of CpG islands |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TET1 | up-regulates quantity by expression
transcriptional regulation
|
HOXA9 |
0.315 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259094 |
|
|
Homo sapiens |
|
pmid |
sentence |
27708339 |
Furthermore, TET1 catalytic domain possessed demethylase activity in cancer cells, being able to inhibit the CpG methylation of tumor suppressor gene (TSG) promoters and reactivate their expression, such as SLIT2, ZNF382 and HOXA9. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TET1 | up-regulates quantity by expression
transcriptional regulation
|
ZNF382 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259095 |
|
|
Homo sapiens |
|
pmid |
sentence |
27708339 |
Furthermore, TET1 catalytic domain possessed demethylase activity in cancer cells, being able to inhibit the CpG methylation of tumor suppressor gene (TSG) promoters and reactivate their expression, such as SLIT2, ZNF382 and HOXA9. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
OGT | up-regulates activity
glycosylation
|
TET1 |
0.456 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259184 |
|
|
Homo sapiens |
HEK-293T Cell |
pmid |
sentence |
23729667 |
The DNA demethylation enzyme Tet1 interacts with Ogt and is O-GlcNAcylated. Tet1 protein stability is positively regulated by O-GlcNAcylation, and its repression function on targeting genes is dependent on Ogt. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TET1 | up-regulates quantity by expression
transcriptional regulation
|
SLIT2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259093 |
|
|
Homo sapiens |
|
pmid |
sentence |
27708339 |
Furthermore, TET1 catalytic domain possessed demethylase activity in cancer cells, being able to inhibit the CpG methylation of tumor suppressor gene (TSG) promoters and reactivate their expression, such as SLIT2, ZNF382 and HOXA9. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |