| + |
AURKB | down-regulates 
phosphorylation
|
KNL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165502 |
Ser24 |
RPVRRRHsSILKPPR |
Homo sapiens |
|
| pmid |
sentence |
| 20471944 |
To determine whether the combinatorial regulation of the kmn network by aurora b observed in vitro is critical to controlling kinetochore-microtubule attachments in vivo, we next investigated the effect of the phosphomimetic (to aspartate) and nonphosphorylatable (to alanine) mutants of dsn1, knl1, and ndc80 in vertebrate cells. We predicted that both types of mutations in critical phosphorylation sites would affect chromosome segregation, since preventing the inactivation of inappropriately attached kinetochores by aurora b (in the nonphosphorylatable mutant) or constitutively inactivating this attachment (in the phosphomimetic mutant). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165506 |
Ser60 |
KKNSRRVsFADTIKV |
Homo sapiens |
|
| pmid |
sentence |
| 20471944 |
To determine whether the combinatorial regulation of the kmn network by aurora b observed in vitro is critical to controlling kinetochore-microtubule attachments in vivo, we next investigated the effect of the phosphomimetic (to aspartate) and nonphosphorylatable (to alanine) mutants of dsn1, knl1, and ndc80 in vertebrate cells. We predicted that both types of mutations in critical phosphorylation sites would affect chromosome segregation, since preventing the inactivation of inappropriately attached kinetochores by aurora b (in the nonphosphorylatable mutant) or constitutively inactivating this attachment (in the phosphomimetic mutant). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KNL1 | up-regulates 
binding
|
BUB1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158894 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17981135 |
Association of the amino and middle domain of blinkin with the tpr domains in the amino termini of bubr1 and bub1 is essential for bubr1 and bub1 to execute their distinct mitotic functions |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KNL1 | form complex 
binding
|
KNL1 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265193 |
|
|
|
|
| pmid |
sentence |
| 27881301 |
KNL1C (known as Spc105 complex in S. cerevisiae) contains the KNL1 and ZWINT subunits. |
|
| Publications: |
1 |
| + |
KNL1 | up-regulates
binding
|
BUB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158378 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17981135 |
Association of the amino and middle domain of blinkin with the tpr domains in the amino termini of bubr1 and bub1 is essential for bubr1 and bub1 to execute their distinct mitotic functions |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
KNL1
- 
- 