| + |
BUB1 | down-regulates activity 
phosphorylation
|
CDC20 |
0.992 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250604 |
Ser153 |
NRLKVLYsQKATPGS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15525512 |
Bub1 directly phosphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically. A Cdc20 mutant with all six Bub1 phosphorylation sites removed is refractory to Bub1-mediated phosphorylation and inhibition in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250605 |
Ser161 |
QKATPGSsRKTCRYI |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15525512 |
Bub1 directly phosphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically. A Cdc20 mutant with all six Bub1 phosphorylation sites removed is refractory to Bub1-mediated phosphorylation and inhibition in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250606 |
Ser41 |
EAAGPAPsPMRAANR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15525512 |
Bub1 directly phosphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically. A Cdc20 mutant with all six Bub1 phosphorylation sites removed is refractory to Bub1-mediated phosphorylation and inhibition in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250607 |
Ser72 |
SKVQTTPsKPGGDRY |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15525512 |
Bub1 directly phosphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically. A Cdc20 mutant with all six Bub1 phosphorylation sites removed is refractory to Bub1-mediated phosphorylation and inhibition in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250608 |
Ser92 |
AAQMEVAsFLLSKEN |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15525512 |
Bub1 directly phosphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically. A Cdc20 mutant with all six Bub1 phosphorylation sites removed is refractory to Bub1-mediated phosphorylation and inhibition in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250609 |
Thr157 |
VLYSQKAtPGSSRKT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15525512 |
Bub1 directly phosphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically. A Cdc20 mutant with all six Bub1 phosphorylation sites removed is refractory to Bub1-mediated phosphorylation and inhibition in vitro. |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| + |
ATM | up-regulates 
phosphorylation
|
BUB1 |
0.474 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177276 |
Ser314 |
SHEDLPAsQERSEVN |
Homo sapiens |
|
| pmid |
sentence |
| 22099307 |
We also demonstrate that mitotically activated atm phosphorylates bub1, a critical kinetochore protein, on ser314. Atm-mediated bub1 ser314 phosphorylation is required for bub1 activity and is essential for the activation of the spindle checkpoint |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
BUB1 | up-regulates activity
phosphorylation
|
BUB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277186 |
Ser969 |
FTAKCETsGFQCVEM |
in vitro |
|
| pmid |
sentence |
| 26658523 |
Conversely, Bub1 is an active kinase regulated by intra-molecular phosphorylation at the P+1 loop. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
BUB1 |
phosphorylation
|
H2AC11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265261 |
Thr121 |
AVLLPKKtESHHKAK |
Homo sapiens |
|
| pmid |
sentence |
| 19965387 |
the localization of hBub1 kinase usually defines the centromere-specific phosphorylation of H2A-T120. Accordingly, hSgo1 localized along the whole chromosome length in H2B-hBub1deltaN cells (Fig. 6D), indicating that H2A-pT120 plays a predominant role in defining shugoshin localization sites on the human chromosomes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | up-regulates
phosphorylation
|
BUB1 |
0.855 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147065 |
Thr609 |
SAAQLAStPFHKLPV |
Homo sapiens |
|
| pmid |
sentence |
| 16760428 |
The plk1-bub1 interaction requires the polo-box domain (pbd) of plk1 and is enhanced by cyclin-dependent kinase 1 (cdk1)-mediated phosphorylation of bub1 at t609 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BUB1 | up-regulates activity
relocalization
|
MAD1L1 |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252017 |
|
|
|
|
| pmid |
sentence |
| 11402067 |
Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity |
|
| Publications: |
1 |
| + |
BUB1 | up-regulates
binding
|
PLK1 |
0.858 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147061 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16760428 |
The plk1-bub1 interaction requires the polo-box domain (pbd) of plk1 and is enhanced by cyclin-dependent kinase 1 (cdk1)-mediated phosphorylation of bub1 at t609 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BUB1 | up-regulates 
|
Mitotic_checkpoint |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168192 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20888775 |
The multidomain protein kinases bub1 and bubr1 (mad3 in yeast, worms and plants) are central components of the mitotic checkpoint for spindle assembly (sac) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
BUB1 | up-regulates activity
relocalization
|
BUB3 |
0.942 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252019 |
|
|
|
|
| pmid |
sentence |
| 11402067 |
Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity |
|
| Publications: |
1 |
| + |
KNL1 | up-regulates
binding
|
BUB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158378 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17981135 |
Association of the amino and middle domain of blinkin with the tpr domains in the amino termini of bubr1 and bub1 is essential for bubr1 and bub1 to execute their distinct mitotic functions |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BUB1 | up-regulates activity
relocalization
|
CENPE |
0.823 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252016 |
|
|
|
|
| pmid |
sentence |
| 11402067 |
Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity |
|
| Publications: |
1 |
| + |
BUB1 | up-regulates activity
relocalization
|
MAD2L1 |
0.958 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252018 |
|
|
|
|
| pmid |
sentence |
| 11402067 |
Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity |
|
| Publications: |
1 |
3.0
BUB1
- 
- 