4.0
Summary
| Name |  NEK11View Modifications |
| Full Name | Serine/threonine-protein kinase Nek11 |
| Synonyms | Never in mitosis A-related kinase 11, NimA-related protein kinase 11 |
| Primary ID | Q8NG66 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Inhibitors | dabrafenib |
| Function | Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CHEK1 | up-regulates 
phosphorylation
|
NEK11 | 0.264 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NEK11 | down-regulates 
phosphorylation
|
CDC25A | 0.419 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | dabrafenib | down-regulates activity
chemical inhibition
|
NEK11 | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |
| + | NEK2 | up-regulates
phosphorylation
|
NEK11 | 0.392 |
| Publications: | 1 | Organism: | Homo Sapiens | |