+ |
LATS1 | up-regulates activity
phosphorylation
|
CDC26 |
0.479 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275472 |
Thr7 |
tRLELKLD |
|
|
pmid |
sentence |
25723520 |
LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C|Overall, these results suggest that LATS1/2 are novel kinases involved in APC/C phosphorylation and indicate a direct regulatory link between LATS1/2 and APC/C|Here, we demonstrate that LATS1 phosphorylates the Thr7 (T7) residue of the APC/C component CDC26 directly |
|
Publications: |
1 |
+ |
LATS2 | up-regulates activity
phosphorylation
|
CDC26 |
0.473 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275474 |
Thr7 |
tRLELKLD |
|
|
pmid |
sentence |
25723520 |
LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C|Overall, these results suggest that LATS1/2 are novel kinases involved in APC/C phosphorylation and indicate a direct regulatory link between LATS1/2 and APC/C |
|
Publications: |
1 |
+ |
CDC26 | form complex
binding
|
APC-c |
0.845 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252011 |
|
|
|
|
pmid |
sentence |
16896351 |
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. |
|
Publications: |
1 |