| + |
LATS1 | down-regulates 
phosphorylation
|
YAP1 |
0.836 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197647 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
LATS1 | up-regulates activity 
phosphorylation
|
YAP1 |
0.836 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274027 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17974916 |
Similarly, knockdown of both Lats1 and Lats2 decreased endogenous YAP phosphorylation (Fig. 3F), thus establishing an important role of Lats in YAP phosphorylation in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
LATS1 | down-regulates activity
phosphorylation
|
MTF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275473 |
Ser152 |
EGCPRTYsTAGNLRT |
|
|
| pmid |
sentence |
| 35027733 |
The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1|the Hippo pathway kinase LATS phosphorylates and inhibits MTF1|LATS phosphorylates MTF1 at S152 and disrupts its association with the promoters of heavy metal response genes, resulting in the loss of heavy metal response gene expression |
|
| Publications: |
1 |
| + |
LATS1 | up-regulates quantity by stabilization
phosphorylation
|
AMOT |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275843 |
Ser175 |
QGHVRSLsERLMQMS |
|
|
| pmid |
sentence |
| 24101513 |
Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3. Such phosphorylation, in turn, enables the ubiquitin ligase atrophin-1 interacting protein (AIP)4 to bind, ubiquitinate, and stabilize Amot130 |
|
| Publications: |
1 |
| + |
LATS1 | down-regulates quantity by destabilization
phosphorylation
|
YAP1 |
0.836 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-218034 |
Ser397 |
TYHSRDEsTDSGLSM |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20048001 |
We show that YAP is phosphorylated by Lats on Ser 381 in one of the HXRXXS motifs, and this phosphorylation provides the priming signal for CK1delta/epsilon to phosphorylate a phosphodegron in YAP. The phosphorylated phosphodegron recruits beta-TRCP, leading to YAP ubiquitination and degradation under conditions of elevated Hippo pathway activity, such as cell contact inhibition |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
NUAK1 | down-regulates
phosphorylation
|
LATS1 |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161792 |
Ser464 |
NIPVRSNsFNNPLGN |
Homo sapiens |
|
| pmid |
sentence |
| 19927127 |
Moreover, we show that nuak1 phosphorylates lats1 at s464 and this has a role in controlling its stabilitycells that constitutively express nuak1 suffer gross aneuploidies and show diminished expression of the genomic stability regulator lats1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUAK2 | down-regulates
phosphorylation
|
LATS1 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161796 |
Ser464 |
NIPVRSNsFNNPLGN |
Homo sapiens |
|
| pmid |
sentence |
| 19927127 |
Phosphorylation at ser-464 by nuak1 and nuak2 leads to decreased protein level and is required to regulate cellular senescence and cellular ploidy |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinB/CDK1 | up-regulates
phosphorylation
|
LATS1 |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216757 |
Ser613 |
EKKQITTsPITVRKN |
Homo sapiens |
|
| pmid |
sentence |
| 12372621 |
Warts is a serine/threonine kinase and a dynamic component of the mitotic apparatus. We have found that cdc2/cyclin b forms a complex with a fraction of warts in the centrosome and phosphorylates the ser613 site of warts during mitosisit can be speculated that phosphorylation of warts by cdc2/cyclin b promotes a protein complex formation on the mitotic apparatus at early mitosis, which may be required for subsequent activation of warts kinase at the metaphase-anaphase transition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | up-regulates
phosphorylation
|
LATS1 |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94160 |
Ser613 |
EKKQITTsPITVRKN |
Homo sapiens |
|
| pmid |
sentence |
| 12372621 |
Warts is a serine/threonine kinase and a dynamic component of the mitotic apparatus. We have found that cdc2/cyclin b forms a complex with a fraction of warts in the centrosome and phosphorylates the ser613 site of warts during mitosisit can be speculated that phosphorylation of warts by cdc2/cyclin b promotes a protein complex formation on the mitotic apparatus at early mitosis, which may be required for subsequent activation of warts kinase at the metaphase-anaphase transition. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LATS1 | down-regulates
phosphorylation
|
WWTR1 |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197643 |
Ser89 |
AQHVRSHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175783 |
Ser89 |
AQHVRSHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activated lats1/2 in turn phosphorylate and inhibit yap/taz transcription co-activators. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK4 | up-regulates
phosphorylation
|
LATS1 |
0.602 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133551 |
Ser909 |
HQRCLAHsLVGTPNY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15688006 |
We show that Mst2 and hWW45 interact with each other in human cells and that both Mst2 and Mst1 are able to phosphorylate Lats1 and Lats2, thereby stimulating Lats kinase activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133555 |
Thr1079 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
| pmid |
sentence |
| 15688006 |
We show that Mst2 and hWW45 interact with each other in human cells and that both Mst2 and Mst1 are able to phosphorylate Lats1 and Lats2, thereby stimulating Lats kinase activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK3 | up-regulates
phosphorylation
|
LATS1 |
0.598 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133544 |
Ser909 |
HQRCLAHsLVGTPNY |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15688006 |
Since the N-terminal half of Lats1 (residues 1588) was dispensable for the activation of Lats1 by Mst2, mass spectrometry was used to identify phosphorylation sites within the C-terminal domain of Lats1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132927 |
Thr1079 |
EHAFYEFtFRRFFDD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15688006 |
Since the N-terminal half of Lats1 (residues 1588) was dispensable for the activation of Lats1 by Mst2, mass spectrometry was used to identify phosphorylation sites within the C-terminal domain of Lats1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
LATS1 | up-regulates activity
phosphorylation
|
CDC26 |
0.483 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275472 |
Thr7 |
tRLELKLD |
|
|
| pmid |
sentence |
| 25723520 |
LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C|Overall, these results suggest that LATS1/2 are novel kinases involved in APC/C phosphorylation and indicate a direct regulatory link between LATS1/2 and APC/C|Here, we demonstrate that LATS1 phosphorylates the Thr7 (T7) residue of the APC/C component CDC26 directly |
|
| Publications: |
1 |
| + |
LATS1 | down-regulates quantity by repression 
transcriptional regulation
|
VEPH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177068 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22055343 |
Melted represses warts transcription to disrupt hippo pathway activity and specify rh5 fate wts and melt repress each other s transcription in a double negative, bistable feedback loop that directs robust expression of either rh5 or rh6 in r8 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Mob1 | up-regulates
binding
|
LATS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
PRKACA | up-regulates
phosphorylation
|
LATS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236991 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23644383 |
Here, we show that cyclic amp (camp)-dependent protein kinase (pka) phosphorylates lats and thereby enhances its activity sufficiently to phosphorylate yap on ser381. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MOB1B | up-regulates
binding
|
LATS1 |
0.917 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169795 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
NF2 | up-regulates
binding
|
LATS1 |
0.718 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202604 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24012335 |
As expected, the nf2-/- fc-912 cells were defective in lats1/2 phosphorylation (figure s2e-f). Subcellular fractionation revealed a significant increase of endogenous lats1/2 in the cytoplasmic relative to the membrane fraction in the nf2-/- fc-912 schwann cells compared to the nf2+/+ fh-912 schwann cells (figure 2e). This localization defect was rescued by re-expression of nf2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
VEPH1 | down-regulates quantity by repression
transcriptional regulation
|
LATS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177074 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22055343 |
Melted represses warts transcription to disrupt hippo pathway activity and specify rh5 fate wts and melt repress each other s transcription in a double negative, bistable feedback loop that directs robust expression of either rh5 or rh6 in r8 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cullin4-RBX1-DDB1 | down-regulates quantity by destabilization
ubiquitination
|
LATS1 |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272229 |
|
|
Homo sapiens |
H-MESO-1 Cell |
| pmid |
sentence |
| 25026211 |
CRL4 DCAF1 ubiquitylates and inhibits Lats. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK3/4 | up-regulates
phosphorylation
|
LATS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270217 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15688006 |
Since the N-terminal half of Lats1 (residues 1–588) was dispensable for the activation of Lats1 by Mst2, mass spectrometry was used to identify phosphorylation sites within the C-terminal domain of Lats1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
MOB1A | up-regulates
binding
|
LATS1 |
0.939 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169752 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
F2R | down-regulates
|
LATS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192045 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22972936 |
Par1 acts through g12/13 and rho gtpase to inhibit the lats1/2 kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
lysophosphatidic acids | down-regulates
|
LATS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198517 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DCAF1 | down-regulates quantity by destabilization
binding
|
LATS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272226 |
|
|
Homo sapiens |
H-MESO-1 Cell |
| pmid |
sentence |
| 25026211 |
CRL4 DCAF1 ubiquitylates and inhibits Lats. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F-actin_assembly | down-regulates
|
LATS1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201522 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23450633 |
Ga12/13 recruitment of rho-gefs causes rhoa activation and f-actin assembly, which promotes lats1/lat2 inactivation by an unknown, but myosin-independent mechanism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
sphingosine 1-phosphate | down-regulates
|
LATS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198550 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GCG | up-regulates 
|
LATS1 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199202 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(R)-adrenaline | up-regulates
|
LATS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199196 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LATS1
- 
- 