3.0
Summary
| Name |  BRSK1View Modifications |
| Full Name | Serine/threonine-protein kinase BRSK1 |
| Synonyms | Brain-selective kinase 1, 2.7.11.26, Brain-specific serine/threonine-protein kinase 1, BR serine/threonine-protein kinase 1, Serine/threonine-protein kinase SAD-B, Synapses of Amphids Defective homolog 1, SAD1 homolog, hSAD1 | KIAA1811, SAD1, SADB |
| Primary ID | Q8TDC3 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | BRSK1 | up-regulates 
phosphorylation
|
TUBG1 | 0.251 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BRSK1 | down-regulates activity 
phosphorylation
|
CDC25C | 0.495 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BRSK1 | down-regulates
phosphorylation
|
CDC25C | 0.495 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BRSK1 | down-regulates
phosphorylation
|
CDC25B | 0.521 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | BRSK1 | down-regulates activity
phosphorylation
|
CDC25B | 0.521 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BRSK1 | up-regulates activity
phosphorylation
|
CAST | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | BRSK1 |
phosphorylation
|
WEE1 | 0.45 |
| Publications: | 1 | Organism: | In Vitro | |
| + | STK11 | up-regulates
phosphorylation
|
BRSK1 | 0.463 |
| Publications: | 1 | Organism: | Homo Sapiens | |