| + |
CyclinB/CDK1 | up-regulates 
phosphorylation
|
CDC25C |
0.854 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216741 |
Ser122 |
DQHLMKCsPAQLLCS |
Homo sapiens |
|
| pmid |
sentence |
| 10864927 |
Activation of human cdc25c at the g2/m transition occurs concomitantly with phosphorylation of five serine/threonine-proline sites: thr48, thr67, ser122, thr130, and ser214, presumably by cdc2-cyclin b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216765 |
Ser214 |
SRSGLYRsPSMPENL |
Homo sapiens |
|
| pmid |
sentence |
| 10864927 |
Activation of human cdc25c at the g2/m transition occurs concomitantly with phosphorylation of five serine/threonine-proline sites: thr48, thr67, ser122, thr130, and ser214, presumably by cdc2-cyclin b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216769 |
Thr130 |
PAQLLCStPNGLDRG |
Homo sapiens |
|
| pmid |
sentence |
| 10864927 |
Activation of human cdc25c at the g2/m transition occurs concomitantly with phosphorylation of five serine/threonine-proline sites: thr48, thr67, ser122, thr130, and ser214, presumably by cdc2-cyclin b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216773 |
Thr48 |
VCPDVPRtPVGKFLG |
Homo sapiens |
|
| pmid |
sentence |
| 10864927 |
Activation of human cdc25c at the g2/m transition occurs concomitantly with phosphorylation of five serine/threonine-proline sites: thr48, thr67, ser122, thr130, and ser214, presumably by cdc2-cyclin b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216777 |
Thr67 |
LSILSGGtPKRCLDL |
Homo sapiens |
|
| pmid |
sentence |
| 10864927 |
Activation of human cdc25c at the g2/m transition occurs concomitantly with phosphorylation of five serine/threonine-proline sites: thr48, thr67, ser122, thr130, and ser214, presumably by cdc2-cyclin b. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| + |
CDK1 | up-regulates
phosphorylation
|
CDC25C |
0.867 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78416 |
Ser122 |
DQHLMKCsPAQLLCS |
Homo sapiens |
|
| pmid |
sentence |
| 10864927 |
Activation of human cdc25c at the g2/m transition occurs concomitantly with phosphorylation of five serine/threonine-proline sites: thr48, thr67, ser122, thr130, and ser214, presumably by cdc2-cyclin b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64960 |
Ser214 |
SRSGLYRsPSMPENL |
Homo sapiens |
|
| pmid |
sentence |
| 10037602 |
Phosphorylation at thr-48, thr-67, ser-122, thr-130, ser-168 and ser-214 occurs at g2 and g2-m transition and is catalyzed by cdk1. Ser-168 phosphorylation levels are lower than those at the other 5 cdk1 sites. Phosphorylation by cdk1 leads to increased activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36267 |
Ser214 |
SRSGLYRsPSMPENL |
Homo sapiens |
|
| pmid |
sentence |
| 8119945 |
Phosphorylation at thr-48, thr-67, ser-122, thr-130, ser-168 and ser-214 occurs at g2 and g2-m transition and is catalyzed by cdk1. Ser-168 phosphorylation levels are lower than those at the other 5 cdk1 sites. Phosphorylation by cdk1 leads to increased activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78420 |
Ser214 |
SRSGLYRsPSMPENL |
Homo sapiens |
|
| pmid |
sentence |
| 10864927 |
Activation of human cdc25c at the g2/m transition occurs concomitantly with phosphorylation of five serine/threonine-proline sites: thr48, thr67, ser122, thr130, and ser214, presumably by cdc2-cyclin b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78424 |
Thr130 |
PAQLLCStPNGLDRG |
Homo sapiens |
|
| pmid |
sentence |
| 10864927 |
Activation of human cdc25c at the g2/m transition occurs concomitantly with phosphorylation of five serine/threonine-proline sites: thr48, thr67, ser122, thr130, and ser214, presumably by cdc2-cyclin b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36271 |
Thr48 |
VCPDVPRtPVGKFLG |
Homo sapiens |
|
| pmid |
sentence |
| 8119945 |
Phosphorylation at thr-48, thr-67, ser-122, thr-130, ser-168 and ser-214 occurs at g2 and g2-m transition and is catalyzed by cdk1. Ser-168 phosphorylation levels are lower than those at the other 5 cdk1 sites. Phosphorylation by cdk1 leads to increased activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78428 |
Thr48 |
VCPDVPRtPVGKFLG |
Homo sapiens |
|
| pmid |
sentence |
| 10864927 |
Activation of human cdc25c at the g2/m transition occurs concomitantly with phosphorylation of five serine/threonine-proline sites: thr48, thr67, ser122, thr130, and ser214, presumably by cdc2-cyclin b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64964 |
Thr48 |
VCPDVPRtPVGKFLG |
Homo sapiens |
|
| pmid |
sentence |
| 10037602 |
Phosphorylation at thr-48, thr-67, ser-122, thr-130, ser-168 and ser-214 occurs at g2 and g2-m transition and is catalyzed by cdk1. Ser-168 phosphorylation levels are lower than those at the other 5 cdk1 sites. Phosphorylation by cdk1 leads to increased activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36275 |
Thr67 |
LSILSGGtPKRCLDL |
Homo sapiens |
|
| pmid |
sentence |
| 8119945 |
Phosphorylation at thr-48, thr-67, ser-122, thr-130, ser-168 and ser-214 occurs at g2 and g2-m transition and is catalyzed by cdk1. Ser-168 phosphorylation levels are lower than those at the other 5 cdk1 sites. Phosphorylation by cdk1 leads to increased activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64968 |
Thr67 |
LSILSGGtPKRCLDL |
Homo sapiens |
|
| pmid |
sentence |
| 10037602 |
Phosphorylation at thr-48, thr-67, ser-122, thr-130, ser-168 and ser-214 occurs at g2 and g2-m transition and is catalyzed by cdk1. Ser-168 phosphorylation levels are lower than those at the other 5 cdk1 sites. Phosphorylation by cdk1 leads to increased activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-78432 |
Thr67 |
LSILSGGtPKRCLDL |
Homo sapiens |
|
| pmid |
sentence |
| 10864927 |
Activation of human cdc25c at the g2/m transition occurs concomitantly with phosphorylation of five serine/threonine-proline sites: thr48, thr67, ser122, thr130, and ser214, presumably by cdc2-cyclin b. |
|
| Publications: |
11 |
Organism: |
Homo Sapiens |
| + |
CDK1 | down-regulates 
phosphorylation
|
CDC25C |
0.867 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36279 |
Ser168 |
SEMKYLGsPITTVPK |
Homo sapiens |
|
| pmid |
sentence |
| 8119945 |
Phosphorylation at thr-48, thr-67, ser-122, thr-130, ser-168 and ser-214 occurs at g2 and g2-m transition and is catalyzed by cdk1. Ser-168 phosphorylation levels are lower than those at the other 5 cdk1 sites. Phosphorylation by cdk1 leads to increased activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64972 |
Ser168 |
SEMKYLGsPITTVPK |
Homo sapiens |
|
| pmid |
sentence |
| 10037602 |
Phosphorylation at thr-48, thr-67, ser-122, thr-130, ser-168 and ser-214 occurs at g2 and g2-m transition and is catalyzed by cdk1. Ser-168 phosphorylation levels are lower than those at the other 5 cdk1 sites. Phosphorylation by cdk1 leads to increased activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK9 | down-regulates
phosphorylation
|
CDC25C |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164093 |
Ser168 |
SEMKYLGsPITTVPK |
Homo sapiens |
|
| pmid |
sentence |
| 20220133 |
Here we show that jnk directly phosphorylates cdc25c at serine 168 during g(2) phase of the cell cycle. Cdc25c phosphorylation by jnk negatively regulates its phosphatase activity and thereby cdk1 activation, enabling a timely control of mitosis onset. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK10 | down-regulates
phosphorylation
|
CDC25C |
0.244 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164085 |
Ser168 |
SEMKYLGsPITTVPK |
Homo sapiens |
|
| pmid |
sentence |
| 20220133 |
Here we show that jnk directly phosphorylates cdc25c at serine 168 during g(2) phase of the cell cycle. Cdc25c phosphorylation by jnk negatively regulates its phosphatase activity and thereby cdk1 activation, enabling a timely control of mitosis onset. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK8 | down-regulates
phosphorylation
|
CDC25C |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164089 |
Ser168 |
SEMKYLGsPITTVPK |
Homo sapiens |
|
| pmid |
sentence |
| 20220133 |
Here we show that jnk directly phosphorylates cdc25c at serine 168 during g(2) phase of the cell cycle. Cdc25c phosphorylation by jnk negatively regulates its phosphatase activity and thereby cdk1 activation, enabling a timely control of mitosis onset. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK3 | up-regulates
phosphorylation
|
CDC25C |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122090 |
Ser191 |
EDQAEEIsDELMEFS |
Homo sapiens |
|
| pmid |
sentence |
| 14968113 |
Cdc25c phosphorylation on serine 191 by plk3 promotes its nuclear translocation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122094 |
Ser198 |
SDELMEFsLKDQEAK |
Homo sapiens |
|
| pmid |
sentence |
| 14968113 |
Cdc25c phosphorylation on serine 191 by plk3 promotes its nuclear translocation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PLK1 | up-regulates
phosphorylation
|
CDC25C |
0.815 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-115993 |
Ser198 |
SDELMEFsLKDQEAK |
Homo sapiens |
|
| pmid |
sentence |
| 11897663 |
The nuclear accumulation of active m-phase promoting factor (mpf) during prophase is thought to be essential for coordinating m-phase events in vertebrate cells. The protein phosphatase cdc25c, an activator of mpf, enters the nucleus to keep mpf active in the nucleus during prophase. these results suggest that plk1 phosphorylates cdc25c on ser198 and regulates nuclear translocation of cdc25c during prophase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinE/CDK2 | up-regulates
phosphorylation
|
CDC25C |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216721 |
Ser214 |
SRSGLYRsPSMPENL |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20530684 |
The cyclin e/cdk2 complex phosphorylates cdc25c on ser(214), leading to its premature activation, which coincides with higher cyclin b/cdk1 and polo-like kinase 1 (plk1) activities in an s-phase-enriched population that result in faster mitotic entry. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 | up-regulates
phosphorylation
|
CDC25C |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165872 |
Ser214 |
SRSGLYRsPSMPENL |
Homo sapiens |
|
| pmid |
sentence |
| 20530684 |
The cyclin e/cdk2 complex phosphorylates cdc25c on ser(214), leading to its premature activation, which coincides with higher cyclin b/cdk1 and polo-like kinase 1 (plk1) activities in an s-phase-enriched population that result in faster mitotic entry. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK3 |
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4.0
CDC25C
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