| + |
FAT3 | up-regulates activity 
binding
|
ABI1 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282698 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 35108541 |
For instance, we find that Fat3 binds to the WRC components Abi1 and WAVE2 and that asymmetric localization of Abi1/2 in the IPL is lost in Fat3Δ™ mutants (Figures 1 and 7). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FAT3 | down-regulates quantity by destabilization 
binding
|
LATS1/2 |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282697 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 36042367 |
The function of Fat3 in regulating neural progenitor proliferation is mediated by Lats kinases. We propose a model in which Fat3 interacts with and suppresses the protein levels and the kinase activity of Lats1/2, thereby stabilizing the downstream effector Yap (Fig. 6B).Intriguingly, our data demonstrate that Fat3 maintains the proper size of progenitor cell pool by inhibiting the Hippo signaling pathway. Our results revealed that Fat3 suppresses the levels of Lats2 proteins and the phosphorylation of Lats1/2 at T1041 and T1079 leading to stabilization of Yap. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FAT3 | up-regulates activity
binding
|
WASF2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282699 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 35108541 |
For instance, we find that Fat3 binds to the WRC components Abi1 and WAVE2 and that asymmetric localization of Abi1/2 in the IPL is lost in Fat3Δ™ mutants (Figures 1 and 7). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
FAT3
- 
- 