Summary

Name ABI1
Full Name Abl interactor 1
Synonyms Abelson interactor 1, Abi-1, Abl-binding protein 4, AblBP4, Eps8 SH3 domain-binding protein, Eps8-binding protein, Nap1-binding protein, Nap1BP, Spectrin SH3 domain-binding protein 1, e3B1 | SSH3BP1
Primary ID Q8IZP0
Links - -
Type protein
Relations 16
Function May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ MAPK1up-regulates img/direct-activation.png phosphorylation ABI1 0.421
Publications: 3 Organism: Homo Sapiens
+ CDK1down-regulates activity img/direct_inhibition.png phosphorylation ABI1 0.43
Publications: 1 Organism: Homo Sapiens
+ CyclinB/CDK1down-regulates activity img/direct_inhibition.png phosphorylation ABI1 0.43
Publications: 1 Organism: Homo Sapiens
+ PTENdown-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation ABI1 0.243
Publications: 2 Organism: Homo Sapiens
+ MAPK3up-regulates img/direct-activation.png phosphorylation ABI1 0.431
Publications: 1 Organism: Homo Sapiens
+ ABL1up-regulates img/direct-activation.png phosphorylation ABI1 0.876
Publications: 1 Organism: Homo Sapiens
+ Gbetaup-regulates img/direct-activation.png phosphorylation ABI1 0.2
Publications: 1 Organism: Homo Sapiens
+ ABI1form complex img/form-complex.png binding WAVE complex 0.856
Publications: 1 Organism: Homo Sapiens
+ ABI1form complex img/form-complex.png binding WRC complex 0.841
Publications: 1 Organism: Homo Sapiens
+ ABI1up-regulates img/direct-activation.png binding ABL1 0.876
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation ABI1 0.2
Publications: 1 Organism: Homo Sapiens
+ ABI1up-regulates img/direct-activation.png binding CBL 0.379
Publications: 1 Organism: Homo Sapiens
+ DTNBP1up-regulates activity img/direct-activation.png binding ABI1 0.36
Publications: 1 Organism: Rattus Norvegicus
Tissue: Hippocampus