| + |
LATS1/2 | down-regulates activity 
phosphorylation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256188 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
LATS1/2 | down-regulates quantity by destabilization
phosphorylation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277636 |
Ser397 |
TYHSRDEsTDSGLSM |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20048001 |
We show that YAP is phosphorylated by Lats on Ser 381 in one of the HXRXXS motifs, and this phosphorylation provides the priming signal for CK1delta/epsilon to phosphorylate a phosphodegron in YAP. The phosphorylated phosphodegron recruits beta-TRCP, leading to YAP ubiquitination and degradation under conditions of elevated Hippo pathway activity, such as cell contact inhibition |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
LATS1/2 | down-regulates activity
phosphorylation
|
WWTR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256187 |
Ser89 |
AQHVRSHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
NF2 | up-regulates activity 
binding
|
LATS1/2 |
0.713 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33058421 |
The Hippo pathway tumor suppressor Merlin/NF2 is known to be regulated by phosphorylation. Here, the E3 ubiquitin ligase NEDD4L is shown to promote Hippo pathway activation via ubiquitination of Merlin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
STK4 | up-regulates
phosphorylation
|
LATS1/2 |
0.655 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
SRC | down-regulates activity
phosphorylation
|
LATS1/2 |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30889378 |
SRC can directly phosphorylate and inhibit LATS |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Integrin Signaling |
| + |
LATS1/2 | down-regulates quantity by repression 
transcriptional regulation
|
VEPH1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269959 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22055343 |
Melted represses warts transcription to disrupt hippo pathway activity and specify rh5 fate wts and melt repress each other s transcription in a double negative, bistable feedback loop that directs robust expression of either rh5 or rh6 in r9 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MOB1A | up-regulates
binding
|
LATS1/2 |
0.943 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269866 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
F2R | down-regulates
|
LATS1/2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269860 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22972936 |
Par1 acts through g12/13 and rho gtpase to inhibit the lats1/2 kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
sphingosine 1-phosphate | down-regulates
|
LATS1/2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269864 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GCG | up-regulates 
|
LATS1/2 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269857 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Mob1 | up-regulates activity
binding
|
LATS1/2 |
0.944 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256186 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling |
| + |
PRKACA | up-regulates
phosphorylation
|
LATS1/2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269863 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 23644383 |
Here, we show that cyclic amp (camp)-dependent protein kinase (pka) phosphorylates lats and thereby enhances its activity sufficiently to phosphorylate yap on ser381. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FAT3 | down-regulates quantity by destabilization
binding
|
LATS1/2 |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282697 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 36042367 |
The function of Fat3 in regulating neural progenitor proliferation is mediated by Lats kinases. We propose a model in which Fat3 interacts with and suppresses the protein levels and the kinase activity of Lats1/2, thereby stabilizing the downstream effector Yap (Fig. 6B).Intriguingly, our data demonstrate that Fat3 maintains the proper size of progenitor cell pool by inhibiting the Hippo signaling pathway. Our results revealed that Fat3 suppresses the levels of Lats2 proteins and the phosphorylation of Lats1/2 at T1041 and T1079 leading to stabilization of Yap. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
(R)-adrenaline | up-regulates
|
LATS1/2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269867 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
F-actin_assembly | down-regulates
|
LATS1/2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269861 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23450633 |
Ga12/13 recruitment of rho-gefs causes rhoa activation and f-actin assembly, which promotes lats1/lat2 inactivation by an unknown, but myosin-independent mechanism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
VEPH1 | down-regulates quantity by repression
transcriptional regulation
|
LATS1/2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269858 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 22055343 |
Melted represses warts transcription to disrupt hippo pathway activity and specify rh5 fate wts and melt repress each other s transcription in a double negative, bistable feedback loop that directs robust expression of either rh5 or rh6 in r9 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK3 | up-regulates
phosphorylation
|
LATS1/2 |
0.634 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269862 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Activation of mst1/2 leads to phosphorylation and activation of their direct substrates, lats1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
MOB1B | up-regulates
binding
|
LATS1/2 |
0.923 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269865 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
lysophosphatidic acids | down-regulates
|
LATS1/2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269868 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 22863277 |
Serum-borne lysophosphatidic acid (lpa) and sphingosine 1-phosphophate (s1p) act through g12/13-coupled receptors to inhibit the hippo pathway kinases lats1/2, thereby activating yap and taz transcription coactivators, which are oncoproteins repressed by lats1/2. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WWC1 | up-regulates activity
binding
|
LATS1/2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263659 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21233212 |
Here, we show that KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif. KIBRA overexpression stimulates the phosphorylation of Yes-associated protein (YAP), the Hippo pathway effector. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
4.0
LATS1/2