4.0
Summary
| Name |  PARD3View Modifications |
| Full Name | Partitioning defective 3 homolog |
| Synonyms | PAR-3, PARD-3, Atypical PKC isotype-specific-interacting protein, ASIP, CTCL tumor antigen se2-5, PAR3-alpha | PAR3, PAR3A |
| Primary ID | Q8TEW0 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCZ | up-regulates 
phosphorylation
|
PARD3 | 0.71 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MARK2 | up-regulates
phosphorylation
|
PARD3 | 0.494 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AURKA | up-regulates
phosphorylation
|
PARD3 | 0.35 |
| Publications: | 1 | Organism: | Homo Sapiens | |