Summary

Name PARD3
Full Name Partitioning defective 3 homolog
Synonyms PAR-3, PARD-3, Atypical PKC isotype-specific-interacting protein, ASIP, CTCL tumor antigen se2-5, PAR3-alpha | PAR3, PAR3A
Primary ID Q8TEW0
Links - -
Type protein
Relations 3
Function Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation PARD3 0.697
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PARD3 0.512
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PARD3 0.36
Publications: 1 Organism: Homo Sapiens