Relation Results

Summary

Name PARD3
Full Name Partitioning defective 3 homolog
Synonyms PAR-3, PARD-3, Atypical PKC isotype-specific-interacting protein, ASIP, CTCL tumor antigen se2-5, PAR3-alpha | PAR3, PAR3A
Primary ID Q8TEW0
Links - -
Type protein
Relations 3
Function Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central rol ...
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Type: Score: Layout: SPV 
0.7040.5020.355PRKCZPARD3MARK2AURKA

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCZup-regulates img/direct-activation.png phosphorylation PARD3 0.704
Identifier Residue Sequence Organism Cell Line
SIGNOR-94523 Ser827 REGFGRQsMSEKRTK Homo sapiens
pmid sentence
These results imply that serine 827 in the apkc binding site of par-3 is a target of apkc and that the regulated interaction between a protein kinase, apkc, and its substrate, par-3, plays an essential role in the establishment of cell polarity
Publications: 1 Organism: Homo Sapiens
+ MARK2up-regulates img/direct-activation.png phosphorylation PARD3 0.502
Identifier Residue Sequence Organism Cell Line
SIGNOR-198742 Ser873 VDDQKAGsPSRDVGP Homo sapiens
pmid sentence
Gab1 brings par1 and par3 into a transient complex, stimulating par3 phosphorylation by par1
Publications: 1 Organism: Homo Sapiens
+ AURKAup-regulates img/direct-activation.png phosphorylation PARD3 0.355
Identifier Residue Sequence Organism Cell Line
SIGNOR-188398 Ser962 SSRSGREsVSTASDQ Homo sapiens Neuron
pmid sentence
Aurora a interacts directly with the atypical protein kinase c binding domain of par3 and phosphorylates it at serine 962. The phosphorylation of par3 at serine 962 contributes to its function in the establishment of neuronal polarity.
Publications: 1 Organism: Homo Sapiens
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