| + |
CSNK1A1 | down-regulates quantity by destabilization 
phosphorylation
|
TIAM1 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276673 |
Ser329 |
DVNAGEGsEFADSGI |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 25124033 |
Phosphorylation of Ser329, Ser334, and Thr340 in Tiam1 is required for its interaction with βTrCP1. The proteolysis of Tiam1 is prevented by βTrCP silencing, inhibition of CK1 and MEK, or mutation of the Tiam1 degron site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEK1/2 | down-regulates quantity by destabilization
phosphorylation
|
TIAM1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276674 |
Ser329 |
DVNAGEGsEFADSGI |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 25124033 |
Phosphorylation of Ser329, Ser334, and Thr340 in Tiam1 is required for its interaction with βTrCP1. The proteolysis of Tiam1 is prevented by βTrCP silencing, inhibition of CK1 and MEK, or mutation of the Tiam1 degron site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1R9B | up-regulates quantity 
binding
|
TIAM1 |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269175 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 12531897 |
Spinophilin binding promotes the plasma membrane localization of Tiam1 and enhances the ability of Tiam1 to activate p70 S6 kinase. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
TIAM1 | up-regulates 
|
RAC1 |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167073 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20654717 |
This smo-tiam1 complex dissociates upon shh-mediated activation of smo, thus allowing tiam1 to activate rac1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
TIAM1 | up-regulates activity
guanine nucleotide exchange factor
|
RAC1 |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260577 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32203420 |
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates
binding
|
TIAM1 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167070 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20654717 |
This latter work suggested that inactive smo prevents rac1 activation by interacting with the rac guanine nucleotide exchange factor (gef) t-lymphoma invasion and metastasis 1 (tiam1). This smo-tiam1 complex dissociates upon shh-mediated activation of smo, thus allowing tiam1 to activate rac1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199192 |
|
|
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 23074268 |
This latter work suggested that inactive smo prevents rac1 activation by interacting with the rac guanine nucleotide exchange factor (gef) t-lymphoma invasion and metastasis 1 (tiam1). This smo-tiam1 complex dissociates upon shh-mediated activation of smo, thus allowing tiam1 to activate rac1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
SRC | up-regulates
phosphorylation
|
TIAM1 |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102354 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 12810717 |
Tiam1 cooperated with src to induce activation of rac1 in vivo and the formation of membrane ruffles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCF-betaTRCP | down-regulates quantity by destabilization
ubiquitination
|
TIAM1 |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276675 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 25124033 |
Phosphorylation of Ser329, Ser334, and Thr340 in Tiam1 is required for its interaction with βTrCP1. The proteolysis of Tiam1 is prevented by βTrCP silencing, inhibition of CK1 and MEK, or mutation of the Tiam1 degron site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TIAM1 | up-regulates
binding
|
RAC1 |
0.74 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94691 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12393875 |
Lpa-induced rac activation requires tiam1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TIAM1
- 
- 