| + |
CDK2 | up-regulates 
phosphorylation
|
ATRIP |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156928 |
Ser224 |
APSVSHVsPRKNPSV |
Homo sapiens |
|
| pmid |
sentence |
| 17638878 |
Atrip is a cdk2 substrate, and cdk2-dependent phosphorylation of s224 regulates the ability of atr-atrip to promote cell cycle arrest in response to dna damage./ One possibility is s224 phosphorylation creates a binding site for another protein involved in the g2-m checkpoint response |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 |
phosphorylation
|
ATRIP |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156932 |
Ser239 |
VIKPEACsPQFGKTS |
Homo sapiens |
|
| pmid |
sentence |
| 17638878 |
Two novel phosphorylation sites on atrip were identified, s224 and s239 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATR | up-regulates
phosphorylation
|
ATRIP |
0.873 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129469 |
Ser68 |
EELDTLAsQALSQCP |
Homo sapiens |
|
| pmid |
sentence |
| 15451423 |
When dna is damaged, the atr-atrip complex is recruited to chromatin and is activated to transduce the checkpoint signal, but the precise kinase activation mechanism remains unknown. Here, we show that atrip is phosphorylated in an atr-dependent manner after genotoxic stimuli. The serine 68 and 72 residues are important for the phosphorylation in vivo and are required exclusively for direct modification by atr in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129473 |
Ser72 |
TLASQALsQCPAAAR |
Homo sapiens |
|
| pmid |
sentence |
| 15451423 |
When dna is damaged, the atr-atrip complex is recruited to chromatin and is activated to transduce the checkpoint signal, but the precise kinase activation mechanism remains unknown. Here, we show that atrip is phosphorylated in an atr-dependent manner after genotoxic stimuli. The serine 68 and 72 residues are important for the phosphorylation in vivo and are required exclusively for direct modification by atr in vitro. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NEK1 | up-regulates activity
binding
|
ATRIP |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275842 |
|
|
|
|
| pmid |
sentence |
| 28426283 |
It was reported that NEK1 associates with ATR/ATRIP and primes it for activation in response to a variety of genotoxic agents |
|
| Publications: |
1 |
| + |
TOPBP1 | up-regulates
binding
|
ATRIP |
0.789 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163214 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20068082 |
Topbp1 directly activates atr/atrip and promotes atr-mediated chk1 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPA2 | up-regulates
binding
|
ATRIP |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163176 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20068082 |
Ssdna lesions are then coated by replication protein a (rpa), recruiting atr/atrip (atr-interacting protein) complexes via recognition and association of rpa-ssdna by atrip. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ATRIP
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- 