Relation Results

Summary

Name ATRIP
Full Name ATR-interacting protein
Synonyms ATM and Rad3-related-interacting protein | AGS1
Primary ID Q8WXE1
Links - -
Type protein
Relations 7
Function Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.

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Type: Score: Layout: SPV 
0.5780.8780.7960.2830.685CDK2ATRIPATRTOPBP1NEK1RPA2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK2up-regulates img/direct-activation.png phosphorylation ATRIP 0.578
Identifier Residue Sequence Organism Cell Line
SIGNOR-156928 Ser224 APSVSHVsPRKNPSV Homo sapiens
pmid sentence
Atrip is a cdk2 substrate, and cdk2-dependent phosphorylation of s224 regulates the ability of atr-atrip to promote cell cycle arrest in response to dna damage./ One possibility is s224 phosphorylation creates a binding site for another protein involved in the g2-m checkpoint response
Publications: 1 Organism: Homo Sapiens
+ CDK2 img/unknown.png phosphorylation ATRIP 0.578
Identifier Residue Sequence Organism Cell Line
SIGNOR-156932 Ser239 VIKPEACsPQFGKTS Homo sapiens
pmid sentence
Two novel phosphorylation sites on atrip were identified, s224 and s239
Publications: 1 Organism: Homo Sapiens
+ ATRup-regulates img/direct-activation.png phosphorylation ATRIP 0.878
Identifier Residue Sequence Organism Cell Line
SIGNOR-129469 Ser68 EELDTLAsQALSQCP Homo sapiens
pmid sentence
When dna is damaged, the atr-atrip complex is recruited to chromatin and is activated to transduce the checkpoint signal, but the precise kinase activation mechanism remains unknown. Here, we show that atrip is phosphorylated in an atr-dependent manner after genotoxic stimuli. The serine 68 and 72 residues are important for the phosphorylation in vivo and are required exclusively for direct modification by atr in vitro.
Identifier Residue Sequence Organism Cell Line
SIGNOR-129473 Ser72 TLASQALsQCPAAAR Homo sapiens
pmid sentence
When dna is damaged, the atr-atrip complex is recruited to chromatin and is activated to transduce the checkpoint signal, but the precise kinase activation mechanism remains unknown. Here, we show that atrip is phosphorylated in an atr-dependent manner after genotoxic stimuli. The serine 68 and 72 residues are important for the phosphorylation in vivo and are required exclusively for direct modification by atr in vitro.
Publications: 2 Organism: Homo Sapiens
+ TOPBP1up-regulates img/direct-activation.png binding ATRIP 0.796
Identifier Residue Sequence Organism Cell Line
SIGNOR-163214 Homo sapiens
pmid sentence
Topbp1 directly activates atr/atrip and promotes atr-mediated chk1 phosphorylation.
Publications: 1 Organism: Homo Sapiens
+ NEK1up-regulates activity img/direct-activation.png binding ATRIP 0.283
Identifier Residue Sequence Organism Cell Line
SIGNOR-275842
pmid sentence
It was reported that NEK1 associates with ATR/ATRIP and primes it for activation in response to a variety of genotoxic agents
Publications: 1
+ RPA2up-regulates img/direct-activation.png binding ATRIP 0.685
Identifier Residue Sequence Organism Cell Line
SIGNOR-163176 Homo sapiens
pmid sentence
Ssdna lesions are then coated by replication protein a (rpa), recruiting atr/atrip (atr-interacting protein) complexes via recognition and association of rpa-ssdna by atrip.
Publications: 1 Organism: Homo Sapiens
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