| + |
SSH1 | up-regulates activity 
dephosphorylation
|
CORO1B |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248763 |
Ser2 |
sFRKVVRQ |
Homo sapiens |
|
| pmid |
sentence |
| 17350576 |
Coronin 1B inhibits filament nucleation by Arp2/3 complex and this inhibition is attenuated by phosphorylation of Coronin 1B at Serine 2, a site targeted by SSH1L. Coronin 1B also directs SSH1L to lamellipodia where SSH1L likely regulates Cofilin activity via dephosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SSH1 | up-regulates
dephosphorylation
|
CORO1B |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153604 |
Ser2 |
sFRKVVRQ |
Homo sapiens |
|
| pmid |
sentence |
| 17350576 |
Coronin 1b inhibits filament nucleation by arp2/3 complex and this inhibition is attenuated by phosphorylation of coronin 1b at serine 2, a site targeted by ssh1l. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SSH1 | up-regulates activity
dephosphorylation
|
CFL1 |
0.781 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248762 |
Ser3 |
sGVAVSDG |
Homo sapiens |
|
| pmid |
sentence |
| 14531860 |
Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.|Cofilin, a key regulator of actin filament dynamics, is inactivated by phosphorylation at Ser-3 by LIM-kinases and is reactivated by dephosphorylation by a family of protein phosphatases, termed Slingshot (SSH). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKD2 | down-regulates 
phosphorylation
|
SSH1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173441 |
Ser937 |
SNLTRSSsSDSIHSV |
Homo sapiens |
|
| pmid |
sentence |
| 21525957 |
Phosphorylation of ser 402 impedes phosphatase activity of slingshot 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKD1 | down-regulates
phosphorylation
|
SSH1 |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186467 |
Ser937 |
SNLTRSSsSDSIHSV |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19567672 |
Pkd-mediated phosphorylation of serines 937 and 978 regulates ssh1l subcellular localization by binding of 14-3-3 proteins 14-3-3 proteins associate with ssh1l when phosphorylated at serines 937 and 978, thereby sequestering ssh1l in the cytoplasm and preventing translocation of the phosphatase to f-actin_rich membrane protrusions |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173437 |
Ser937 |
SNLTRSSsSDSIHSV |
Homo sapiens |
|
| pmid |
sentence |
| 21525957 |
Phosphorylation of ser 402 impedes phosphatase activity of slingshot 1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186471 |
Ser978 |
SPLKRSHsLAKLGSL |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19567672 |
Pkd-mediated phosphorylation of serines 937 and 978 regulates ssh1l subcellular localization by binding of 14-3-3 proteins 14-3-3 proteins associate with ssh1l when phosphorylated at serines 937 and 978, thereby sequestering ssh1l in the cytoplasm and preventing translocation of the phosphatase to f-actin_rich membrane protrusions |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PRKD1 | down-regulates activity
phosphorylation
|
SSH1 |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275936 |
Ser978 |
SPLKRSHsLAKLGSL |
|
|
| pmid |
sentence |
| 21832093 |
Active PKD Isoforms Phosphorylate and Inactivate SSH1L|Here, we show that active PKD3 also mediates SSH1L phosphorylation at Ser-978 and binding to 14-3-3, further confirming the involvement of all three PKD isoforms in negatively regulating this phosphatase |
|
| Publications: |
1 |
| + |
PRKD3 | down-regulates activity
phosphorylation
|
SSH1 |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275938 |
Ser978 |
SPLKRSHsLAKLGSL |
|
|
| pmid |
sentence |
| 21832093 |
Active PKD Isoforms Phosphorylate and Inactivate SSH1L|Here, we show that active PKD3 also mediates SSH1L phosphorylation at Ser-978 and binding to 14-3-3, further confirming the involvement of all three PKD isoforms in negatively regulating this phosphatase |
|
| Publications: |
1 |
| + |
PRKD2 | down-regulates activity
phosphorylation
|
SSH1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275937 |
Ser978 |
SPLKRSHsLAKLGSL |
|
|
| pmid |
sentence |
| 21832093 |
Active PKD Isoforms Phosphorylate and Inactivate SSH1L|Here, we show that active PKD3 also mediates SSH1L phosphorylation at Ser-978 and binding to 14-3-3, further confirming the involvement of all three PKD isoforms in negatively regulating this phosphatase |
|
| Publications: |
1 |
| + |
PRKD1 | up-regulates activity
phosphorylation
|
SSH1 |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275939 |
Ser99 |
KLAVRLEsAWADRVR |
|
|
| pmid |
sentence |
| 23841590 |
Protein kinase D-mediated phosphorylation at Ser99 regulates localization of p21-activated kinase n the present study, we add another level of complexity to PAK4 regulation by showing that phosphorylation at Ser99 is required for its targeting to the leading edge. This phosphorylation is mediated by PKD1 (protein kinase D1). Phosphorylation of PAK4 at Ser99 also mediates binding to 14-3-3 protein, and is required for the formation of a PAK4-LIMK-PKD1 complex that regulates cofilin activity and directed cell migration| |
|
| Publications: |
1 |
| + |
IRS4 | up-regulates activity
binding
|
SSH1 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277617 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 25100728 |
Insulin Receptor Substrate-4 Binds to Slingshot-1 Phosphatase and Promotes Cofilin Dephosphorylation. In addition, IRS4 co-localized with SSH1 in F-actin-rich membrane protrusions in insulin-stimulated cells, which suggests that the association of IRS4 with SSH1 contributes to localized activation of cofilin in membrane protrusions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SSH1 | down-regulates activity
dephosphorylation
|
LIMK1 |
0.613 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277096 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23153585 |
In addition to its cofilin\u2013phosphatase activity, SSH1 can also dephosphorylate LIMK1 and LIMK2, although LIMK1 is a better substrate than LIMK2 [63] .|SSH1 suppresses the kinase activity of LIMK1 toward cofilin by dephosphorylation at Thr 508 in the kinase catalytic domain and other autophosphorylated residues [63]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SSH1
- 
- 