Summary

Name CFL1
Full Name Cofilin-1
Synonyms 18 kDa phosphoprotein, p18, Cofilin, non-muscle isoform | CFL
Primary ID P23528
Links - -
Type protein
Relations 17
Pathways Axon guidance
Function Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation CFL1 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png phosphorylation CFL1 0.523
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CFL1 0.809
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CFL1 0.55
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation CFL1 0.466
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png dephosphorylation CFL1 0.71
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CFL1 0.727
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CFL1 0.758
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CFL1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CFL1 0.779
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CFL1 0.575
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation CFL1 0.262
Publications: 1 Organism: In Vitro
Pathways:Axon guidance
+ down-regulates img/indirect_inhibition.png Axonal_growth_cone_formation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ down-regulates quantity img/direct_inhibition.png binding F-actin_assembly 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation CFL1 0.2
Publications: 1 Organism: In Vitro
Pathways:Axon guidance