| + |
TFAP2B | down-regulates quantity by repression 
transcriptional regulation
|
ADIPOQ |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255421 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19325541 |
A transcription factor, TFAP2B, has been shown to participate in the regulation of adipocyte metabolism, by facilitating glucose uptake and lipid accumulation, while simultaneously reducing insulin sensitivity, and recently a direct function for TFAP2B as an inhibitor of adiponectin expression was observed. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFAP2B | up-regulates quantity by expression 
transcriptional regulation
|
PTGDS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255425 |
|
|
Homo sapiens |
TE-671 Cell |
| pmid |
sentence |
| 15743775 |
Deletion and mutation of the AP-2 element at -98 in the L-PGDS gene promoter result in a drastic decrease in the reporter activity (Figs. 1 and 2). Results from the EMSA and ChIP assay demonstrated that AP-2β bound to the AP-2 element both in vitro and in TE671 cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFAP2B | up-regulates quantity by stabilization 
binding
|
TP53 |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255422 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21556774 |
These data suggest that AP-2β enhances transactivation of p53 and regulates CRYAB transcription via p53. Further study demonstrated that AP-2β interacts with p53 and augments its protein stability. Taken together, our results indicate that AP-2β up-regulates the transcription of the CRYAB gene through stabilizing p53. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFAP2B | up-regulates quantity by expression
transcriptional regulation
|
CRYAB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253637 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21556774 |
Aberrant expression of CRYAB has been shown to be associated with several neurological diseases and malignant neoplasms. To identify transcriptional regulators of CRYAB expression, we examined its promoter for binding sites of transcription factors and identified four potential AP-2 binding sites in addition to a p53 binding site reported previously|Taken together, our results indicate that AP-2_ up-regulates the transcription of the CRYAB gene through stabilizing p53 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TFAP2B
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