Summary

Name ADIPOQ
Full Name Adiponectin
Synonyms 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, ACRP30, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein | ACDC, ACRP30, APM1, GBP28
Primary ID Q15848
Links - -
Type protein
Relations 5
Function Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding ADIPOR1 0.666
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ADIPOQ 0.374
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ADIPOR2 0.765
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png palmitoylation ADIPOQ 0.2
Publications: 1 Organism: Homo Sapiens