Summary

Name TM9SF4
Full Name Transmembrane 9 superfamily member 4
Synonyms Tumor cannibalism associated protein 1 | KIAA0255, TUCAP1
Primary ID Q92544
Links - -
Type protein
Relations 4
Function Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding MTOR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATP6V1H 0.275
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation TM9SF4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Autophagy 0.7
Publications: 1 Organism: Homo Sapiens