+ |
TM9SF4 | down-regulates activity
binding
|
MTOR |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266703 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
29125601 |
TM9SF4 inhibited mTOR activity in HEK293 cells. Under nutrient starvation, TM9SF4 functions to facilitate mTOR inactivation, resulting in an enhanced autophagic flux, which serves to protect cells from apoptotic cell death. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TM9SF4 | up-regulates activity
binding
|
ATP6V1H |
0.275 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266885 |
|
|
Homo sapiens |
HCT-116 Cell, SW-480 Cell |
pmid |
sentence |
25659576 |
Here, we demonstrate that TM9SF4 represents a novel V-ATPase-associated protein involved in V-ATPase activation. We have observed in HCT116 and SW480 colon cancer cell lines that TM9SF4 interacts with the ATP6V1H subunit of the V-ATPase V1 sector. Suppression of TM9SF4 with small interfering RNAs strongly reduces assembly of V-ATPase V0/V1 sectors, thus reversing tumor pH gradient with a decrease of cytosolic pH, alkalization of intracellular vesicles and a reduction of extracellular acidity. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
HIF1A | down-regulates quantity by repression
transcriptional regulation
|
TM9SF4 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266705 |
|
|
Homo sapiens |
Acute Myeloid Leukemia Cell |
pmid |
sentence |
25961573 |
Here, we investigated the impact of hypoxia on TM9SF4 expression in leukemic cells and identified TM9SF4 as a direct target of HIF-1α, downregulated in these cells by hypoxia. Then, we found that the hypoxia-mediated downregulation of TM9SF4 expression is associated with a decrease of cell adhesion of leukemic cells to fibronectin, thus demonstrating that human TM9SF4 is a new molecule involved in leukemic cell adhesion. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TM9SF4 | up-regulates
|
Autophagy |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266704 |
|
|
Homo sapiens |
|
pmid |
sentence |
29125601 |
In the present study, we report a novel autophagy-related protein TM9SF4, which plays a functional role in the induction phase of autophagic process. Overexpression of TM9SF4 promoted autophagic flux in HEK293 cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |