Summary

Name ATP6V1H
Full Name V-type proton ATPase subunit H
Synonyms V-ATPase subunit H, Nef-binding protein 1, NBP1, Protein VMA13 homolog, V-ATPase 50/57 kDa subunits, Vacuolar proton pump subunit H, Vacuolar proton pump subunit SFD |
Primary ID Q9UI12
Links - -
Type protein
Relations 5
Function Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding V-ATPase 0.791
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ATP6V1H 0.275
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ATP6V1H 0.31
Publications: 1
+ up-regulates activity img/direct-activation.png binding AP-2 complex 0.228
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding TGFBR1 0.2
Publications: 1 Organism: Mus Musculus