| + |
TOPBP1 | up-regulates activity 
binding
|
ATR |
0.807 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263232 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 16530042 |
These results establish that TopBP1 can activate both Xenopus and human ATR. Furthermore, these experiments provide conclusive evidence that the kinase activity that is induced by TopBP1 is intrinsic to the ATR protein itself and is not due to a kinase that associates with ATR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MUTYH | up-regulates
binding
|
TOPBP1 |
0.388 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173972 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21615992 |
Binding of myh directly participates in atr and topbp1 activation in dna damage signaling, leading to apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TOPBP1 | up-regulates
binding
|
ATRIP |
0.79 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163214 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20068082 |
Topbp1 directly activates atr/atrip and promotes atr-mediated chk1 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAD1 | up-regulates
binding
|
TOPBP1 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179379 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18594563 |
The 9-1-1 complex functions as a clamp, encircling the dna, and recruits the brct domain-containing protein topbp1 in a phospho-dependent manner |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAD9A | up-regulates
binding
|
TOPBP1 |
0.821 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179382 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18594563 |
The 9-1-1 complex functions as a clamp, encircling the dna, and recruits the brct domain-containing protein topbp1 in a phospho-dependent manner |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UBR5 | down-regulates quantity by destabilization 
polyubiquitination
|
TOPBP1 |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272667 |
|
|
in vitro |
|
| pmid |
sentence |
| 11714696 |
Using an in vitro reconstitution, specific E2 (ubiquitin-conjugating) enzymes (human UbcH4, UbcH5B, and UbcH5C) transferred ubiquitin molecules to hHYD, leading to the ubiquitination of TopBP1. TopBP1 was usually ubiquitinated and degraded by the proteosome, whereas X-irradiation diminished the ubiquitination of TopBP1 probably via the phosphorylation, resulting in the stable colocalization of up-regulated TopBP1 with gamma-H2AX nuclear foci in DNA breaks. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PHF8 | up-regulates quantity by stabilization
binding
|
TOPBP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273657 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 33511404 |
TopBP1 Interacts with PHF8 through residue R1314 of TopBP1. Importantly, PHF8 regulates TopBP1 protein level by preventing its ubiquitination and degradation mediated by the E3 ligase UBR5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TOPBP1 | form complex 
binding
|
BRCA1-B complex |
0.659 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263218 |
|
|
|
|
| pmid |
sentence |
| 25400280 |
Another BRCA1 complex, the BRCA1–B complex containing BRCA1/TopBP1 and BACH1 (also known and BRIP1/FANCJ) has been reported to play a role in HR and S‐phase cell cycle arrest. The exact role of this complex in HR remains unclear, although it is assumed that BACH1, a DNA helicase, contributes to end resection (possibly through its helicase activity) and RPA loading, whereas TopBP1 is required for ATR activation and subsequent S‐phase checkpoint activation |
|
| Publications: |
1 |
| + |
FANCM | up-regulates
relocalization
|
TOPBP1 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164765 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20372056 |
The enzymatic activity of fan cm is then required to remodel and stabilize the fork to allow topbp1 access to activate atr , in a 9-1-1-independent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TOPBP1
- 
- 