Relation Results

Summary

Name LPAR1
Full Name Lysophosphatidic acid receptor 1
Synonyms LPA receptor 1, LPA-1, Lysophosphatidic acid receptor Edg-2 | EDG2, LPA1
Primary ID Q92633
Links - -
Type protein
Relations 21
Inhibitors 3-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acid
Function Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of th ...
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Type: Score: Layout: SPV 
0.4330.80.5240.4380.5370.80.4340.80.4970.4110.4110.414LPAR1GNA13lysophosphatidic acidsGNAQGNA12GNAI1lysophosphatidic acidGNA153-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic acidGNAI3GNA14GNAO1NME1

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Relations
Regulator
Mechanism
target
score ℹ
+ LPAR1up-regulates activity img/direct-activation.png binding GNA13 0.433
Identifier Residue Sequence Organism Cell Line
SIGNOR-257400 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ lysophosphatidic acidsup-regulates img/direct-activation.png chemical activation LPAR1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-138582 Homo sapiens
pmid sentence
Lpa exerts its downstream signaling by binding to the lpa(1), lpa(2), and lpa(3) (formerly edg-2, -4, and -7) family of seven-transmembrane, segmented, heterotrimeric guanine nucleotide-binding protein (g protein)-coupled receptors.
Identifier Residue Sequence Organism Cell Line
SIGNOR-37365 Rattus norvegicus Rat-1 Cell
pmid sentence
LPA activates its own G protein-coupled receptor(s) leading to stimulation of phospholipase C and inhibition of adenylate cyclase.
Identifier Residue Sequence Organism Cell Line
SIGNOR-198523 Homo sapiens
pmid sentence
Lpa binds to a family of gpcrs known as lpa receptors (lpa1-6) to initiate intracellular signaling. Lpa1 was highly expressed and lpa3 was detectable in hek293a cells compared to other lpa receptors.
Publications: 3 Organism: Homo Sapiens, Rattus Norvegicus
+ LPAR1up-regulates activity img/direct-activation.png binding GNAQ 0.524
Identifier Residue Sequence Organism Cell Line
SIGNOR-257091 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ LPAR1up-regulates img/direct-activation.png binding GNA12 0.438
Identifier Residue Sequence Organism Cell Line
SIGNOR-198507 Homo sapiens
pmid sentence
Serum-borne lysophosphatidic acid (LPA) and sphingosine 1-phosphophate (S1P) act through G12/13-coupled receptors to inhibit the Hippo pathway kinases Lats1/2, thereby activating YAP and TAZ transcription.
Identifier Residue Sequence Organism Cell Line
SIGNOR-164679 Homo sapiens
pmid sentence
The receptor, now called lpa1, is a gpcr that couples to heterotrimeric g proteins (gi, gq, g12/13alpha subunits).
Identifier Residue Sequence Organism Cell Line
SIGNOR-236988 Mus musculus
pmid sentence
Lysophosphatidic acid (lpa), a major g protein coupled receptor (gpcr)-activating ligand present in serum, elicits growth factor like responses by stimulating specific gpcrs coupled to heterotrimeric g proteins such as g(i), g(q), and g12/13.
Publications: 3 Organism: Homo Sapiens, Mus Musculus
+ LPAR1up-regulates activity img/direct-activation.png binding GNA12 0.438
Identifier Residue Sequence Organism Cell Line
SIGNOR-257345 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ LPAR1up-regulates activity img/direct-activation.png binding GNAI1 0.537
Identifier Residue Sequence Organism Cell Line
SIGNOR-256696 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ lysophosphatidic acidup-regulates activity img/direct-activation.png chemical activation LPAR1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257528 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ LPAR1up-regulates img/direct-activation.png binding GNAQ 0.524
Identifier Residue Sequence Organism Cell Line
SIGNOR-164682 Homo sapiens
pmid sentence
The receptor, now called lpa1, is a gpcr that couples to heterotrimeric g proteins (gi, gq, g12/13alpha subunits)
Publications: 1 Organism: Homo Sapiens
+ LPAR1up-regulates activity img/direct-activation.png binding GNA15 0.434
Identifier Residue Sequence Organism Cell Line
SIGNOR-257282 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ LPAR1up-regulates img/direct-activation.png binding GNA13 0.433
Identifier Residue Sequence Organism Cell Line
SIGNOR-236985 Mus musculus NIH-3T3 Cell
pmid sentence
Lysophosphatidic acid (lpa), a major g protein coupled receptor (gpcr)-activating ligand present in serum, elicits growth factor like responses by stimulating specific gpcrs coupled to heterotrimeric g proteins such as g(i), g(q), and g12/13.
Identifier Residue Sequence Organism Cell Line
SIGNOR-230761 Homo sapiens
pmid sentence
The receptor, now called lpa1, is a gpcr that couples to heterotrimeric g proteins (gi, gq, g12/13alpha subunits).
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ 3-[({4-[4-({[1-(2-chlorophenyl)ethoxy]carbonyl}amino)-3-methyl-1,2-oxazol-5-yl]phenyl}methyl)sulfanyl]propanoic aciddown-regulates img/direct_inhibition.png chemical inhibition LPAR1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-193558 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ LPAR1up-regulates activity img/direct-activation.png binding GNAI3 0.497
Identifier Residue Sequence Organism Cell Line
SIGNOR-256839 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ LPAR1up-regulates activity img/direct-activation.png binding GNA14 0.411
Identifier Residue Sequence Organism Cell Line
SIGNOR-257200 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ LPAR1up-regulates img/direct-activation.png binding GNAI1 0.537
Identifier Residue Sequence Organism Cell Line
SIGNOR-94635 Homo sapiens
pmid sentence
We conclude that lpa(1) receptors couple to a g(i)-phosphoinositide 3-kinase-tiam1 pathway to activate rac.
Publications: 1 Organism: Homo Sapiens
+ LPAR1up-regulates activity img/direct-activation.png binding GNAO1 0.411
Identifier Residue Sequence Organism Cell Line
SIGNOR-256975 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ NME1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation LPAR1 0.414
Identifier Residue Sequence Organism Cell Line
SIGNOR-255163 Homo sapiens MDA-MB-435 Cell
pmid sentence
To elucidate the molecular mechanism of Nm23-H1 motility suppression, expression microarray analysis of an MDA-MB-435 cancer cell line overexpressing wild-type Nm23-H1 was done and cross-compared with expression profiles from lines expressing the P96S and S120G mutants. Nine genes, MET, PTN, SMO, FZD1, L1CAM, MMP2, NETO2, CTGF, and EDG2, were down-regulated by wild-type but not by mutant Nm23-H1 expression.
Publications: 1 Organism: Homo Sapiens
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