| + |
DPF2 | down-regulates activity 
binding
|
ESRRA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-239539 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 25713408 |
DPF2 directly bound to ERRalpha and suppressed the transactivation function of nuclear receptors such as androgen receptor. DPF2 was recruited to ERR target gene promoters in myoblast cells, and knockdown of DPF2 derepressed the level of mRNA expressed by target genes of ERRalpha. These results show that DPF2 acts as a nuclear receptor-selective co-repressor for ERRalpha by associating with both acetylated histone H3 and HDAC1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DPF2 | up-regulates activity 
binding
|
SWI/SNF complex |
0.626 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261963 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20460684 |
Our current findings indicate that REQ is a novel adaptor protein that links the Brm-type SWI/SNF complex and RelB/p52 and operates at the most downstream stages of the noncanonical NF-κB pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DPF2 | down-regulates 
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261969 |
|
|
Homo sapiens |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 24332853 |
Here, DPF2 appears to be another important regulator of myeloid differentiation that can cooperate with PRMT4 to maintain the “stemness” of HSPCs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DPF2 | up-regulates activity
binding
|
NfKb-p65/p50 |
0.307 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261964 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20460684 |
REQ is required for the oncogenic activity induced by RelB/p52. . Through in vitro binding experiments, REQ was found to bind to several SWI/SNF complex subunits and also to the p52 NF-κB subunit through its nuclear localization signal containing the N-terminal region. In this study, we present evidence that REQ is a specific adaptor protein that links RelB/p52 with Brm-type SWI/SNF complexes and thereby plays pivotal roles at the most downstream stages of the noncanonical NF-κB pathway. We further show that REQ is required for oncogenesis in several human tumor cell lines in which the noncanonical NF-κB pathway is aberrantly regulated.REQ and Brm specifically promote RelB/p52-dependent transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DPF2 | form complex 
binding
|
Embryonic stem cell-specific SWI/SNF |
0.602 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270719 |
|
|
Mus musculus |
Embryonic Stem Cell |
| pmid |
sentence |
| 19279220 |
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DPF2 | down-regulates activity
binding
|
RUNX1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261966 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24332853 |
The interaction between RUNX1 and DPF2 is dependent on the RUNX1 methylation status |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DPF2
- 
- 