Relation Results

Summary

Name RAD50
Full Name DNA repair protein RAD50
Synonyms hRAD50
Primary ID Q92878
Links - -
Type protein
Relations 8
Pathways DNA repair in cancer
Function Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and ...
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Type: Score: Layout: SPV 
0.8120.4740.9130.8120.3050.20.786ATMRAD50RINT1MRE11/RAD50/NBS1RBL2MRE11BRCA1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ ATM img/unknown.png phosphorylation RAD50 0.812
Identifier Residue Sequence Organism Cell Line
SIGNOR-156077 Ser635 KLFDVCGsQDFESDL Homo sapiens
pmid sentence
The ms/ms fragmentation spectra (figure s7) confirmed the phosphorylation of rad50 at the predicted atm substrate site, s635, in agreement with published data
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer
+ RAD50up-regulates activity img/direct-activation.png binding RINT1 0.474
Identifier Residue Sequence Organism Cell Line
SIGNOR-265030 Homo sapiens HFF-1 Cell
pmid sentence
We propose that p130, forming a complex with Rad50 through RINT-1, blocks telomerase-independent telomere lengthening in normal cells. 
Publications: 1 Organism: Homo Sapiens
+ RAD50form complex img/form-complex.png binding MRE11/RAD50/NBS1 0.913
Identifier Residue Sequence Organism Cell Line
SIGNOR-251506
pmid sentence
The mre11_rad50_nbs1 (mrn) complex is among the earliest respondents to dna double-strand breaks (dsbs). To organize the mrn complex, the mre11 exonuclease directly binds nbs1, dna, and rad50.
Publications: 1
Pathways:DNA repair in cancer
+ RAD50up-regulates img/direct-activation.png binding ATM 0.812
Identifier Residue Sequence Organism Cell Line
SIGNOR-175053 Homo sapiens
pmid sentence
One of the earliest events is recruitment and activation of the atm at the damaged dna sites through the mre11rad50nbs1 (mrn) sensor complex. . the mre11/rad50/nbs1 (mrn) complex maintains genomic stability by bridging dna ends and initiating dna damage signaling through activation of the atm kinase.
Identifier Residue Sequence Organism Cell Line
SIGNOR-181634 Homo sapiens
pmid sentence
One of the earliest events is recruitment and activation of the atm at the damaged dna sites through the mre11rad50nbs1 (mrn) sensor complex. . the mre11/rad50/nbs1 (mrn) complex maintains genomic stability by bridging dna ends and initiating dna damage signaling through activation of the atm kinase.
Publications: 2 Organism: Homo Sapiens
Pathways:DNA repair in cancer
+ RBL2up-regulates activity img/direct-activation.png binding RAD50 0.305
Identifier Residue Sequence Organism Cell Line
SIGNOR-265029 Homo sapiens HFF-1 Cell
pmid sentence
We propose that p130, forming a complex with Rad50 through RINT-1, blocks telomerase-independent telomere lengthening in normal cells. 
Publications: 1 Organism: Homo Sapiens
+ RAD50up-regulates img/direct-activation.png binding MRE11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-157478 Homo sapiens
pmid sentence
To organize the mrn complex, the mre11 exonuclease directly binds nbs1, dna, and rad50.
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer
+ RAD50up-regulates img/direct-activation.png binding BRCA1 0.786
Identifier Residue Sequence Organism Cell Line
SIGNOR-69701 Homo sapiens Breast Cancer Cell
pmid sentence
Brca1 interacts in vitro and in vivo with hrad50. Brca1 is important for the cellular responses to dna damage that are mediated by the hrad50-hmre11-p95 complex.
Publications: 1 Organism: Homo Sapiens
Pathways:DNA repair in cancer
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