Summary

Name RBL2
Full Name Retinoblastoma-like protein 2
Synonyms 130 kDa retinoblastoma-associated protein, p130, Retinoblastoma-related protein 2, RBR-2, pRb2 | RB2
Primary ID Q08999
Links - -
Type protein
Relations 27
Function Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation RBL2 0.666
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RBL2 0.842
Publications: 12 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RBL2 0.842
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation RBL2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell_cycle_block 0.7
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding RAD50 0.307
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination RBL2 0.54
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RBL2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation MYOD1 0.38
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png dephosphorylation RBL2 0.556
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RBL2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Cell_cycle_progress 0.7
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png transcriptional regulation RBL2 0.298
Publications: 1 Organism: Homo Sapiens