| + |
CDK6 |
phosphorylation
|
RBL2 |
0.667 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104711 |
Ser1035 |
NMDAPPLsPYPFVRT |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. all three residues selectively targeted by cdk4(6), t401 (n-terminus), s672 (spacer region) and s1035 (c-terminus) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104715 |
Ser672 |
TLYDRYSsPPASTTR |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. all three residues selectively targeted by cdk4(6), t401 (n-terminus), s672 (spacer region) and s1035 (c-terminus) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104719 |
Thr401 |
SKALRIStPLTGVRY |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. all three residues selectively targeted by cdk4(6), t401 (n-terminus), s672 (spacer region) and s1035 (c-terminus) |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CDK2 |
phosphorylation
|
RBL2 |
0.843 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104660 |
Ser1044 |
YPFVRTGsPRRIQLS |
Homo sapiens |
|
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. site-directed mutagenesis of s1044 to an alanine resulted in the specific loss of d5 when this mutant was ectopically expressed in t98g cells and labelled by [32p]orthophosphate (figure 4b), proving that phosphorylation of s1044 gave rise to the tryptic phosphopeptide d5: tgspr. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104667 |
Ser1068 |
HKNETMLsPREKIFY |
Homo sapiens |
|
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104671 |
Ser1080 |
IFYYFSNsPSKRLRE |
Homo sapiens |
|
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104675 |
Ser413 |
VRYIKENsPCVTPVS |
Homo sapiens |
|
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104679 |
Ser639 |
DEICIAGsPLTPRRV |
Homo sapiens |
|
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104683 |
Ser662 |
GLGRSITsPTTLYDR |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104687 |
Ser688 |
RLFVENDsPSDGGTP |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104691 |
Ser952 |
DSRSHQNsPTELNKD |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104695 |
Thr1097 |
SMIRTGEtPTKKRGI |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104699 |
Thr417 |
KENSPCVtPVSTATH |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104703 |
Thr642 |
CIAGSPLtPRRVTEV |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104707 |
Thr694 |
DSPSDGGtPGRMPPQ |
Homo sapiens |
|
| pmid |
sentence |
| 11157749 |
We now identify 22 in vivo phosphorylation sites of p130, targeted by diverse kinases, and present evidence for three cyclin-dependent kinase 4(6) [cdk4(6)] specific phosphorylations, which appear critical for controlling the growth-restraining activity of p130. |
|
| Publications: |
12 |
Organism: |
Homo Sapiens |
| + |
CDK2 | down-regulates 
phosphorylation
|
RBL2 |
0.843 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87492 |
Ser1112 |
LLEDGSEsPAKRICP |
Homo sapiens |
|
| pmid |
sentence |
| 12006580 |
When expressed in u2os cells, the phosphorylation-deficient mutant p130(delta)(cdk4), in which the cdk4 specific sites were mutated to alanine residues, imposed a more sustained g1 arrest than a constitutively active prb(delta)(cdk), known to repress all cellular e2f activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104656 |
Ser1112 |
LLEDGSEsPAKRICP |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 11157749 |
When expressed in u2os cells, the phosphorylation-deficient mutant p130(delta)(cdk4), in which the cdk4 specific sites were mutated to alanine residues, imposed a more sustained g1 arrest than a constitutively active prb(delta)(cdk), known to repress all cellular e2f activity |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | up-regulates quantity 
transcriptional regulation
|
RBL2 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238606 |
|
|
Homo sapiens |
NIH-3T3 Cell |
| pmid |
sentence |
| 11884591 |
Here we show that the Forkheads AFX (FOXO4) and FKHR-L1 (FOXO3a) also directly control transcription of the retinoblastoma-like p130 protein and cause upregulation of p130 protein expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCF-SKP2 | down-regulates quantity by destabilization
polyubiquitination
|
RBL2 |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272598 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 12435635 |
The activity of the ubiquitin ligase complex Skp1-Cul1/Cdc53-F-box protein Skp2 (SCF(Skp2)) and the proteasome were necessary for p130 degradation. In vitro, recombinant Skp2 was able to bind hyperphosphorylated but not dephosphorylated p130. Furthermore, in vitro polyubiquitination of p130 by SCF(Skp2) was specifically dependent on phosphorylation of p130 on Serine 672. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2CA | up-regulates
dephosphorylation
|
RBL2 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129752 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15467457 |
Pocket protein family consists of the retinoblastoma tumor suppressor protein (prb) and the functionally and structurally related proteins p107 and p130./dephosphorylation of p130 and p107 in cell extracts is inhibited by concentrations of okadaic acid known to inhibit pp2a, but not pp1. Finally, the pp2a catalytic subunit pp2a/c) specifically interacts with both p130 and p107 / the cell cycle repressor activity of pocket proteins is inactivated by cdk mediated phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TWIST2 | down-regulates quantity by repression 
transcriptional regulation
|
RBL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255509 |
|
|
Homo sapiens |
HGC-27 Cell |
| pmid |
sentence |
| 19051271 |
we performed microarray analysis to compare the gene expression profiles in HGC-27 cells, with or without small interfering RNA (siRNA)-mediated depletion of TWIST. Our results showed that NF1, RAP1A, SRPX, RBL2, PFDN4, ILK, F2R, ERBB3, and MYB were up-regulated, whereas AKR1C2, FOS, GDF15, NR2F1, ATM, and CTPS were down-regulated after TWIST depletion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBL2 | down-regulates quantity
transcriptional regulation
|
MYOD1 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241943 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10801445 |
Furthermore, muscle cells overexpressing p130 had reduced levels of the muscle-promoting factor MyoD. In addition, p130 repressed the transactivation capacity of MyoD, an effect abolished by co-transfection of pRb |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TWIST1 | down-regulates quantity by repression
transcriptional regulation
|
RBL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255535 |
|
|
Homo sapiens |
HGC-27 Cell |
| pmid |
sentence |
| 19051271 |
we performed microarray analysis to compare the gene expression profiles in HGC-27 cells, with or without small interfering RNA (siRNA)-mediated depletion of TWIST. Our results showed that NF1, RAP1A, SRPX, RBL2, PFDN4, ILK, F2R, ERBB3, and MYB were up-regulated, whereas AKR1C2, FOS, GDF15, NR2F1, ATM, and CTPS were down-regulated after TWIST depletion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBL2 | up-regulates 
|
Cell_cycle_block |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267287 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10801445 |
Although forced expression of either p130 or pRb in mouse C2 myoblasts efficiently blocked cell cycle progression, only p130 inhibited the differentiation program. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO | up-regulates quantity
transcriptional regulation
|
RBL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252934 |
|
|
Homo sapiens |
NIH-3T3 Cell |
| pmid |
sentence |
| 11884591 |
Here we show that the Forkheads AFX (FOXO4) and FKHR-L1 (FOXO3a) also directly control transcription of the retinoblastoma-like p130 protein and cause upregulation of p130 protein expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBL2 | up-regulates activity
binding
|
RAD50 |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265029 |
|
|
Homo sapiens |
HFF-1 Cell |
| pmid |
sentence |
| 16600870 |
We propose that p130, forming a complex with Rad50 through RINT-1, blocks telomerase-independent telomere lengthening in normal cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBL2 | down-regulates
|
Cell_cycle_progress |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241946 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10801445 |
Although forced expression of either p130 or pRb in mouse C2 myoblasts efficiently blocked cell cycle progression, only p130 inhibited the differentiation program. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
RBL2
- 
- 