| + |
HES5 | down-regulates quantity by repression 
transcriptional regulation
|
NEUROG1 |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265141 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 30030829 |
The basic-helixloop-helix factors HES1 and HES5 repress the expression of the proneural genes (Ascl1, Atoh1, Neurog1 and Neurog2) and thereby inhibit NSCs differentiation and neuron production |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NEUROG1 | up-regulates 
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265172 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 18400164 |
While the mechanisms by which Ngn2 promotes neurogenesis have been characterized, little is known about how Ngn2 confers neuronal cell-type identity during spinal cord development. Ngn1 and Ngn2, two mammalian orthologs of the Drosophila proneural bHLH gene atonal, are expressed in overlapping patterns throughout the developing nervous system and act as important regulators of developmental neurogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| Pathways: | Retinoic acid Signaling |
| + |
NEUROG3 | up-regulates quantity by expression
transcriptional regulation
|
NEUROG1 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254632 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19028584 |
Ngn3 overexpression altered the expression of a number of regulatory genes, including ash1, ath3, ath5, chx10, neuroD, ngn1, ngn2, and NSCL1. Early gene ngn1 was induced, but ash1, ngn2, ath3, and chx10, whose expressions persist through later phases of neurogenesis, were down-regulated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEUROG1 | up-regulates quantity by expression 
transcriptional regulation
|
NEUROD2 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266235 |
|
|
Mus musculus |
P-19 Cell |
| pmid |
sentence |
| 10814830 |
Based on these results, we concluded that the transactivation of the NDRF gene by ngn1 is mediated through the E4 box, suggesting that the E4 box and its binding bHLH protein(s) may play an important role in the transcriptional regulation of the NDRF gene. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CHD8 | down-regulates quantity 
transcriptional regulation
|
NEUROG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268919 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32839322 |
Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and Chd8−/− NPCs, and several other Sox TF members (Sox2, Sox7, and Sox11) became derepressed in the Chd8−/− cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
NEUROG1 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265140 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 30030829 |
The basic-helixloop-helix factors HES1 and HES5 repress the expression of the proneural genes (Ascl1, Atoh1, Neurog1 and Neurog2) and thereby inhibit NSCs differentiation and neuron production |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Retinoic acid Signaling |
3.0
NEUROG1
- 
- 