| + |
PRKCA | down-regulates activity 
phosphorylation
|
HES1 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248992 |
Ser37 |
TASEHRKsSKPIMEK |
in vitro |
|
| pmid |
sentence |
| 9389649 |
Endogenous HES-1 DNA-binding activity is post-translationally inhibited during NGF signaling in vivo, and phosphorylation of PKC consensus sites in the HES-1 DNA-binding domain inhibits DNA binding by purified HES-1 in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248993 |
Ser38 |
ASEHRKSsKPIMEKR |
in vitro |
|
| pmid |
sentence |
| 9389649 |
Endogenous HES-1 DNA-binding activity is post-translationally inhibited during NGF signaling in vivo, and phosphorylation of PKC consensus sites in the HES-1 DNA-binding domain inhibits DNA binding by purified HES-1 in vitro. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
IKBKB | up-regulates quantity by expression 
transcriptional regulation
|
HES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22056382 |
Tnf-α enhanced the transcriptional activity of a classical Notch target gene via Ikk2 by inducing histone H3 phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates activity
|
NR3C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253064 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 24300895 |
Altering the expression of HES1 did not obviously affect GR abundance (Figure 3A). However, genome-wide microarrays revealed that overexpression of HES1 resulted in inhibition of GR-mediated changes in the glucocorticoid regulated transcriptome, as compared to non-overexpressing controls |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates quantity by repression 
transcriptional regulation
|
MYOD1 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235596 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10066785 |
Notch signaling up-regulated hes1 mrna expression within 1 h and subsequently reduced expression of myod mrna. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis |
| + |
CDK8 | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130637 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15546612 |
Cycc:cdk8 and cyct1:cdk9/p-tefb are recruited with notch and associated coactivators (mam, skip) to the hes1 promoter in signaling cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates
binding
|
RBPJ |
0.584 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146684 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16682003 |
Here we show that hrt2 and hes1 interact with rbp-jkappa to negatively regulate notch-dependent activation of hrt and hes expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCNC | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130589 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15546612 |
Cycc:cdk8 and cyct1:cdk9/p-tefb are recruited with notch and associated coactivators (mam, skip) to the hes1 promoter in signaling cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC1 | down-regulates quantity
transcriptional regulation
|
HES1 |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253054 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18762022 |
These data suggest that the GR recruits cellular HDAC activities to the Hes1 promoter, thereby conferring transcriptional repression in response to GC signaling. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NOTCH1 | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183507 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19165418 |
Several lines of evidence have suggested that these genes are indeed direct notch target genes: a) the promoters of hes1, hes5 and hes7 as well as hey1, hey2 and heyl subfamily of hes, related with yrpw motif) can be activated by a constitutive active form of notch1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML, NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
ASCL1 |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265146 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 30030829 |
The basic-helixloop-helix factors HES1 and HES5 repress the expression of the proneural genes (Ascl1, Atoh1, Neurog1 and Neurog2) and thereby inhibit NSCs differentiation and neuron production |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254824 |
|
|
Homo sapiens |
Neuroblastoma Cell |
| pmid |
sentence |
| 11054669 |
Our data show that functional sympathetic neuronal differentiation of neuroblastoma cells is associated with transient activation of HES-1 and down-regulation of HASH-1 expression. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | Retinoic acid Signaling |
| + |
NHLH2 | down-regulates quantity by repression
transcriptional regulation
|
HES1 |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254828 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21573214 |
Luciferase reporter assay demonstrated that the co-expression of LMO3 and HEN2 attenuates HES1 (a negative regulator for Mash1)-dependent reduction of luciferase activity driven by the Mash1 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
E2F1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189061 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19891787 |
We earlier identified e2f-1 as a crucial transcription factor directly inhibited by hes-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
ATOH1 |
0.485 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265144 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 30030829 |
The basic-helixloop-helix factors HES1 and HES5 repress the expression of the proneural genes (Ascl1, Atoh1, Neurog1 and Neurog2) and thereby inhibit NSCs differentiation and neuron production |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254742 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14614508 |
HES-1 is a direct CREB target in vivo. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Liver |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
NR3C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251674 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19129776 |
HES1 binding to the promoter of the NC3C1 gene inhibits its expression and results in insufficient production of the encoded glucocorticoid receptor- rendering these cells resistant to treatment with dexamethasone |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBPJ | up-regulates quantity by expression 
binding
|
HES1 |
0.584 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71168 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10520600 |
These results indicate that the two Hes genes are essential effectors for the Notch pathway and that neuronal differentiation is controlled by the pathway Notch-Hes1/Hes5-|Mash1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254743 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 14614508 |
Overexpression of HES-1 fully repressed PPAR-g even in the presence of the ACREB inhibitor, showing that HES-1 acts downstream of CREB |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
RCAN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252026 |
|
|
Mus musculus |
Keratinocyte |
| pmid |
sentence |
| 15866158 |
Increased Calcineurin/NFAT activity by Notch signaling involves downregulation of Calcipressin, an endogenous Calcineurin inhibitor, through a HES-1-dependent mechanism .... Chromatin immunoprecipitation (ChIP) analysis of keratinocytes overexpressing HES-1 showed that this protein can bind to the HES binding sites present in both distal and proximal promoters |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IKK-complex | up-regulates quantity by expression
|
HES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253586 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22056382 |
Tnf-α enhanced the transcriptional activity of a classical Notch target gene via Ikk2 by inducing histone H3 phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCNT1 | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130634 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15546612 |
Cycc:cdk8 and cyct1:cdk9/p-tefb are recruited with notch and associated coactivators (mam, skip) to the hes1 promoter in signaling cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
NEUROG2 |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265142 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 30030829 |
The basic-helixloop-helix factors HES1 and HES5 repress the expression of the proneural genes (Ascl1, Atoh1, Neurog1 and Neurog2) and thereby inhibit NSCs differentiation and neuron production |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Retinoic acid Signaling |
| + |
MAML2 | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94276 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12386158 |
Similarly, maml1 and maml2 amplified notch ligand (both jagged2 and delta1)-induced transcription of the hes-1 gene, whereas maml3 displayed little effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYT1L | down-regulates quantity by repression
transcriptional regulation
|
HES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266775 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 28379941 |
ChIP–seq experiments showed that 80% of Myt1l targets, including the transcription factor Hes1, were co-bound by the repressive Sin3b–HDAC1 complex early during reprogramming |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NfKb-p65/p50 | up-regulates quantity
transcriptional regulation
|
HES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253063 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 24300895 |
These data indicate that basal NFκB activity at the conserved +26/+34 site of the HES1 gene promotes its expression, and that glucocorticoids can silence HES1 by inhibiting this activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
DTX1 |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164071 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20208568 |
The notch target gene hes1 causes transcriptional inhibition of deltex1 by directly binding to the promoter of deltex1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Osteosarcoma Cell |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis |
| + |
HES1 | down-regulates quantity
transcriptional regulation
|
NOC3L |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253059 |
|
|
Sus scrofa |
Mesenchymal Stem Cell |
| pmid |
sentence |
| 23611667 |
The expression level of FAD24 is inversely associated with that of HES1 in porcine MSCs after adipogenic induction. Enforced overexpression of HES1 in MSCs during the early stage of adipogenesis significantly repressed the transcription of FAD24 (P < 0.01) and the other pro-adipogenic genes |
|
| Publications: |
1 |
Organism: |
Sus Scrofa |
| + |
NOTCH3 | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174750 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 21743488 |
We demonstrate that her2 overexpression in this cellular model of dcis drives transcriptional upregulation of multiple components of the notch survival pathway. Importantly, luminal filling required upregulation of a signaling pathway comprising notch3, its cleaved intracellular domain and the transcriptional regulator hes1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
NEUROG1 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265140 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 30030829 |
The basic-helixloop-helix factors HES1 and HES5 repress the expression of the proneural genes (Ascl1, Atoh1, Neurog1 and Neurog2) and thereby inhibit NSCs differentiation and neuron production |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Retinoic acid Signaling |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
CTNND2 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251877 |
|
|
Mus musculus |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 21106062 |
Coordinated regulation of δ-catenin expression by both the activating transcription factor E2F1 and repressive transcription factor Hes1 in prostate cancer progression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HES1 | down-regulates activity
transcriptional regulation
|
MYOD1 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243181 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10066785 |
Notch signaling up-regulated HES1 mRNA expression within 1 h and subsequently reduced expression of MyoD mRNA |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis |
| + |
GATA6 | up-regulates quantity by expression
|
HES1 |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253153 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 24317510 |
Many GATA6-dependent genes lacked nearby binding sites but several strongly dependent, synexpressed and GATA6-bound genes encode TFs such as MYC, HES1, RARB and CDX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates activity
binding
|
RBPJ/NOTCH |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209756 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16682003 |
Here we show that hrt2 and hes1 interact with rbp-jkappa to negatively regulate notch-dependent activation of hrt and hes expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Heart |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
PTGDS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255424 |
|
|
Homo sapiens |
TE-671 Cell |
| pmid |
sentence |
| 15743775 |
knock-down of Hes-1 mRNA by RNA interference significantly enhanced the L-PGDS mRNA level, indicating that the L-PGDS gene expression is repressed by the Notch-Hes signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK9 | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130703 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15546612 |
Cycc:cdk8 and cyct1:cdk9/p-tefb are recruited with notch and associated coactivators (mam, skip) to the hes1 promoter in signaling cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNF | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253605 |
|
|
Homo sapiens |
Rheumatoid Arthritis Disease Specific Synovial Fibroblast |
| pmid |
sentence |
| 22190977 |
Exposure of RA FLSs to TNF-α (10 ng/ml) led to increase of Hes-1, a target gene of Notch signaling, and a marked upregulation of Notch 2, Delta-like 1, and Delta-like 3 mRNA levels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
FLT3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261563 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25234168 |
We then found that Hes1 directly bound to the promoter region of the FMS-like tyrosine kinase 3 (FLT3) gene and downregulated the promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
HES1 | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253058 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 16282371 |
Notch signaling blocks differentiation of 3T3-L1 preadipocytes, and this can be mimicked by constitutive expression of the Notch target gene Hes-1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
LMO3 | down-regulates quantity by repression
transcriptional regulation
|
HES1 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254826 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21573214 |
Luciferase reporter assay demonstrated that the co-expression of LMO3 and HEN2 attenuates HES1 (a negative regulator for Mash1)-dependent reduction of luciferase activity driven by the Mash1 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209590 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7566092 |
Here we show that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-J kappa (refs 8,9) and act as transcriptional activators through the KBF2-binding sites of the HES-1 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling |
| + |
RBPJ | up-regulates quantity
transcriptional regulation
|
HES1 |
0.584 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243178 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10066785 |
ligand-induced Notch signaling up-regulated HES1 mRNA expression within 1h and subsequently reduced expression of MyoD mRNA |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HES1 | down-regulates quantity by repression
transcriptional regulation
|
PPARG |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253584 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14614508 |
CREB inhibits hepatic PPAR-gamma expression in the fasted state by stimulating the expression of the Hairy Enhancer of Split (HES-1) gene, a transcriptional repressor that is shown here to be a mediator of fasting lipid metabolism in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| + |
NOTCH | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261534 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32195003 |
Notch signaling is initiated by the interaction of Notch ligands and receptors on adjacent cells, which further triggers two proteolytic cleavage events. The first cleavage releases a functional extracellular domain (NECD); the second cleavage, mediated by γ-secretase, releases the intracellular domain (NICD) into the cytoplasm. The NICD then translocates to the nucleus, binds to the transcription factor CBF/Su (H)/LAG-2 (CSL), and recruits Mastermind-like protein 1 and p300/CBP to induce transcription of Notch target genes, including Hes1, p21, Akt, cyclin D1, and mTOR |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
3.0
HES1
- 
- 