3.0
Retinoic acid Signaling
Pathway ID: SIGNOR-RAS
Description: Retinoic Acid (RA) promotes neurogenesis by regulating the switch between proliferation and differentiation. RA binds to retinoic acid receptors (e.g. RARA, RARB and RARG) which in turn bind and activate coreceptor RXRA. RXRA downstream effects include inhibition of proliferation, inhibition of NOTCH and the restoring of expression of neurogenic genes such as NEUROG1 and NEUROG2.
Curated by: Livia Perfetto
Description: Retinoic Acid (RA) promotes neurogenesis by regulating the switch between proliferation and differentiation. RA binds to retinoic acid receptors (e.g. RARA, RARB and RARG) which in turn bind and activate coreceptor RXRA. RXRA downstream effects include inhibition of proliferation, inhibition of NOTCH and the restoring of expression of neurogenic genes such as NEUROG1 and NEUROG2.
Curated by: Livia Perfetto
14 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| RXRA | P19793 |
| RARA | P10276 |
| RARB | P10826 |
| NEUROG2 | Q9H2A3 |
| Proliferation | SIGNOR-PH4 |
| RBPJ/NOTCH | SIGNOR-C97 |
| NEUROG1 | Q92886 |
| CTNNB1 | P35222 |
| HES1 | Q14469 |
| ASCL1 | P50553 |
| RARG | P13631 |
| NOTCH1 | P46531 |
| Neurogenesis | SIGNOR-PH168 |
| all-trans-retinoic acid | CHEBI:15367 |