| + |
PRKACA | up-regulates activity 
phosphorylation
|
CUL5 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250352 |
Ser730 |
MKMRKKIsNAQLQTE |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10898738 |
Elimination of the S730 but not the T325 PKA phosphorylation site of VACM-1 resulted in a complete inhibition of the VACM-1 activity, thus suggesting a direct effect of PKA on the VACM-1 receptor. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
NAE | up-regulates activity
neddylation
|
CUL5 |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243166 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
The family of cullin proteins is the most established target for NEDD8. In humans, it is composed of seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), whereas PARC (CUL9) and APC2 (component of the anaphase promoting complex APC) contain a cullin-homology domain. All cullins are modified with NEDD8The role of cullin NEDDylation is to enhance the activity of the CRLs and subsequent ubiquitination and degradation of the regulated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CUL5 | down-regulates quantity by destabilization 
polyubiquitination
|
DAB1 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272140 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 24210661 |
SOCS7 promotes Dab1 polyubiquitylation and degradation. SOCS7-CRL5 complexes stimulate the ubiquitylation and turnover of Dab1. SOCS7, a CRL5 substrate adaptor protein, is also required for neocortical layering. SOCS7-CRL5 complexes stimulate the ubiquitylation and turnover of Dab1. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
SAG | up-regulates quantity by stabilization
binding
|
CUL5 |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272844 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25216516 |
Here we report that NEDD4-1, a HECT domain-containing E3 ubiquitin ligase, binds via its HECT domain directly with SAG's C-terminal RING domain and ubiquitylates SAG for proteasome-mediated. We also found that SAG bridges NEDD4-1 via its C-terminus and CUL-5 via its N-terminus to form a NEDD4-1/SAG/CUL-5 tri-complex. Biologically, NEDD4-1 overexpression sensitizes cancer cells to etoposide-induced apoptosis by reducing SAG levels through targeted degradation. Thus, SAG is added to a growing list of NEDD4-1 substrates and mediates its biological function. degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CUL5 | form complex 
binding
|
Elongin E3-Cul-5 |
0.929 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271798 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 19300455 |
Here, we provide the first evidence that a novel ASB2 isoform, ASB2beta, is important for muscle differentiation. ASB2beta is expressed in muscle cells during embryogenesis and in adult tissues. ASB2beta is part of an active E3 ubiquitin ligase complex and targets the actin-binding protein filamin B (FLNb) for proteasomal degradation. Altogether, our results indicated that ASB2β can assemble with elongin B, elongin C, Cullin 5 and Rbx2 to reconstitute an active E3 ubiquitin ligase complex.ASB2β induces polyubiquitylation of FLNb. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CUL5 | up-regulates activity
binding
|
ARIH2 |
0.514 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268843 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24076655 |
Here, we provide evidence that Ariadne RBR E3 ubiquitin ligases such as TRIAD1 and HHARI can bind and be activated by CRL complexes. Whereas TRIAD1 specifically associates with CUL5–RBX2, HHARI is more promiscuous towards cullin types and associates with RBX1-associated cullins 1, 2, 3, and 4A. Interestingly, both TRIAD1 and HHARI show a strong preference for binding the neddylated form of the cullin. Our data suggest a novel function of NEDD8 in directing specific CRLs to Ariadne RBR ligases, which in turn exert influence on the levels of their cognate neddylated cullin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOCS4 | up-regulates activity
binding
|
CUL5 |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272141 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 24210661 |
SOCS7 promotes Dab1 polyubiquitylation and degradation. SOCS7-CRL5 complexes stimulate the ubiquitylation and turnover of Dab1. SOCS7, a CRL5 substrate adaptor protein, is also required for neocortical layering. SOCS7-CRL5 complexes stimulate the ubiquitylation and turnover of Dab1. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
3.0
CUL5
- 
- 