| + |
PRKACA | down-regulates activity 
phosphorylation
|
STMN2 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250056 |
Ser50 |
KQINKRAsGQAFELI |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 9525956 |
Using in vitro phosphorylated recombinant protein, four phosphorylation sites were identified in the SCG10 sequence. Ser-50 and Ser-97 were the target sites for protein kinase A. phosphorylation negatively regulates the microtubule-depolymerizing activity of SCG10 and that all four sites participate in this regulation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250057 |
Ser97 |
AAEERRKsQEAQVLK |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 9525956 |
Using in vitro phosphorylated recombinant protein, four phosphorylation sites were identified in the SCG10 sequence. Ser-50 and Ser-97 were the target sites for protein kinase A. phosphorylation negatively regulates the microtubule-depolymerizing activity of SCG10 and that all four sites participate in this regulation |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
MAPK10 | down-regulates
phosphorylation
|
STMN2 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112110 |
Ser62 |
ELILKPPsPISEAPR |
Homo sapiens |
|
| pmid |
sentence |
| 11718727 |
We demonstrate that purified scg10 can be phosphorylated by two subclasses of mitogen-activated protein (map) kinases, c-jun n-terminal/stress-activated protein kinase (jnk/sapk) and p38 map kinase;jnk3/sapkbeta phosphorylation occurs at ser-62 and ser-73, residues that result in reduced microtubule-destabilizing activity for scg10. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112114 |
Ser73 |
EAPRTLAsPKKKDLS |
Homo sapiens |
|
| pmid |
sentence |
| 11718727 |
We demonstrate that purified scg10 can be phosphorylated by two subclasses of mitogen-activated protein (map) kinases, c-jun n-terminal/stress-activated protein kinase (jnk/sapk) and p38 map kinase;jnk3/sapkbeta phosphorylation occurs at ser-62 and ser-73, residues that result in reduced microtubule-destabilizing activity for scg10. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | down-regulates activity
phosphorylation
|
STMN2 |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249115 |
Ser62 |
ELILKPPsPISEAPR |
Rattus norvegicus |
Brain |
| pmid |
sentence |
| 9525956 |
SCG10, a growth cone-enriched MT-destabilizing protein, has been recently characterized as an in vitro substrate for various serine/threonine kinases including PKA, MAP kinase, and CDK (19). We have found that SCG10 is phosphorylated in vivo in developing rat brain.| The sites for MAP kinase phosphorylation were identified as Ser-62 and Ser-73 of SCG10|By expressing a series of phosphorylation site mutants, we showed that the MT-destabilizing effect of SCG10 could be modulated. While the nonphosphorylatable mutant showed higher activity than the wild-type protein, the activity of the mutant in which phosphorylation on all four sites was mimicked by an aspartate residue was greatly reduced. These data suggest that the nonphosphorylated state of SCG10 represents the most active form of the protein. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249116 |
Ser73 |
EAPRTLAsPKKKDLS |
Rattus norvegicus |
Brain |
| pmid |
sentence |
| 9525956 |
SCG10, a growth cone-enriched MT-destabilizing protein, has been recently characterized as an in vitro substrate for various serine/threonine kinases including PKA, MAP kinase, and CDK (19). We have found that SCG10 is phosphorylated in vivo in developing rat brain.| The sites for MAP kinase phosphorylation were identified as Ser-62 and Ser-73 of SCG10|By expressing a series of phosphorylation site mutants, we showed that the MT-destabilizing effect of SCG10 could be modulated. While the nonphosphorylatable mutant showed higher activity than the wild-type protein, the activity of the mutant in which phosphorylation on all four sites was mimicked by an aspartate residue was greatly reduced. These data suggest that the nonphosphorylated state of SCG10 represents the most active form of the protein. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus |
3.0
STMN2
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