+ |
NEK2 | down-regulates activity
phosphorylation
|
LRRC45 |
0.38 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273707 |
Ser661 |
VLAYVQAsPVRTLSP |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
24035387 |
Moreover, LRRC45 interacts with both C-Nap1 and rootletin and is phosphorylated by Nek2A at S661 during mitosis. After phosphorylation, both LRRC45 centrosomal localization and fiber-like structures are significantly reduced, which subsequently leads to centrosome separation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CCDC102B | up-regulates activity
binding
|
LRRC45 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275627 |
|
|
|
|
pmid |
sentence |
30404835 |
CCDC102B is recruited to the centrosome by C-Nap1 (also known as CEP250) and interacts with the centrosome linker components rootletin and LRRC45. CCDC102B decorates and facilitates the formation of rootletin filaments. Furthermore, CCDC102B is phosphorylated by Nek2A (an isoform encoded by NEK2) and is disassociated from the centrosome at the onset of mitosis. |
|
Publications: |
1 |
+ |
LRRC45 | up-regulates activity
binding
|
CEP250 |
0.419 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273703 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
24035387 |
Here, we show that LRRC45 is a centrosome linker that localizes at the proximal ends of the centrioles and forms fiber-like structures between them. Depletion of LRRC45 results in centrosome splitting during interphase. LRRC45 interacts with C-Nap1 and rootletin |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
LRRC45 | up-regulates activity
binding
|
CROCC |
0.453 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273704 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
24035387 |
Here, we show that LRRC45 is a centrosome linker that localizes at the proximal ends of the centrioles and forms fiber-like structures between them. Depletion of LRRC45 results in centrosome splitting during interphase. LRRC45 interacts with C-Nap1 and rootletin |
|
Publications: |
1 |
Organism: |
Homo Sapiens |