| + |
AKT | up-regulates activity 
phosphorylation
|
DOCK6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275667 |
Ser1194 |
GQRSRLAsMLDSDTE |
|
|
| pmid |
sentence |
| 23462102 |
Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons|At later developmental stages, the abundance of the kinase Akt increased, resulting in the binding of Akt to Dock6 and the phosphorylation of Dock6 at Ser(1194). | In dorsal root ganglion neurons from mice lacking Dock6, reintroduction of Dock6 with a nonphosphorylatable S1194A mutation rescued axon extension but not branch number, whereas reintroduction of Dock6 with a phosphomimetic S1194E mutation resulted in premature branching |
|
| Publications: |
1 |
| + |
PP2CA_R1A_R2A | down-regulates activity 
phosphorylation
|
DOCK6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275668 |
Ser1194 |
GQRSRLAsMLDSDTE |
|
|
| pmid |
sentence |
| 23462102 |
Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons|At later developmental stages, the abundance of the kinase Akt increased, resulting in the binding of Akt to Dock6 and the phosphorylation of Dock6 at Ser(1194). | In dorsal root ganglion neurons from mice lacking Dock6, reintroduction of Dock6 with a nonphosphorylatable S1194A mutation rescued axon extension but not branch number, whereas reintroduction of Dock6 with a phosphomimetic S1194E mutation resulted in premature branching |
|
| Publications: |
1 |
| + |
AKT1 | up-regulates activity
phosphorylation
|
DOCK6 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275666 |
Ser1194 |
GQRSRLAsMLDSDTE |
|
|
| pmid |
sentence |
| 23462102 |
Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons|At later developmental stages, the abundance of the kinase Akt increased, resulting in the binding of Akt to Dock6 and the phosphorylation of Dock6 at Ser(1194). | In dorsal root ganglion neurons from mice lacking Dock6, reintroduction of Dock6 with a nonphosphorylatable S1194A mutation rescued axon extension but not branch number, whereas reintroduction of Dock6 with a phosphomimetic S1194E mutation resulted in premature branching |
|
| Publications: |
1 |
| + |
PPP2CA | down-regulates activity
phosphorylation
|
DOCK6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275669 |
Ser1194 |
GQRSRLAsMLDSDTE |
|
|
| pmid |
sentence |
| 23462102 |
Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons|At later developmental stages, the abundance of the kinase Akt increased, resulting in the binding of Akt to Dock6 and the phosphorylation of Dock6 at Ser(1194). | In dorsal root ganglion neurons from mice lacking Dock6, reintroduction of Dock6 with a nonphosphorylatable S1194A mutation rescued axon extension but not branch number, whereas reintroduction of Dock6 with a phosphomimetic S1194E mutation resulted in premature branching |
|
| Publications: |
1 |
| + |
DOCK6 | up-regulates activity
guanine nucleotide exchange factor
|
CDC42 |
0.659 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275671 |
|
|
|
|
| pmid |
sentence |
| 23462102 |
Dock6 is a guanine nucleotide exchange factor (GEF) that activates the Rho family guanosine triphosphatases Rac1 and Cdc42 to regulate the actin cytoskeleton. |
|
| Publications: |
1 |
| + |
DOCK6 | up-regulates activity
guanine nucleotide exchange factor
|
RAC1 |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275670 |
|
|
|
|
| pmid |
sentence |
| 23462102 |
Dock6 is a guanine nucleotide exchange factor (GEF) that activates the Rho family guanosine triphosphatases Rac1 and Cdc42 to regulate the actin cytoskeleton. |
|
| Publications: |
1 |
3.0
DOCK6
- 
- 