Summary

Name KLHL15
Full Name Kelch-like protein 15
Synonyms | KIAA1677
Primary ID Q96M94
Links - -
Type protein
Relations 4
Function Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:27561354, PubMed:14528312, PubMed:35219381). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation (PubMed:27561354, PubMed:35219381). Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354, PubMed:35219381). {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:23135275, ECO:0000269|PubMed:27561354, ECO:0000269|PubMed:35219381}.

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Relations

Regulator Mechanism target score ℹ
+ KLHL15down-regulates quantity by destabilization img/direct_inhibition.png binding PPP2R5B 0.2
Publications: 1 Organism: Homo Sapiens
+ KLHL15down-regulates quantity by destabilization img/direct_inhibition.png binding RBBP8 0.492
Publications: 1 Organism: Homo Sapiens
+ KLHL15up-regulates activity img/direct-activation.png binding Cullin 3-RBX1-Skp1 0.473
Publications: 2 Organism: Homo Sapiens