3.0
Summary
| Name |  PPP2R5BView Modifications |
| Full Name | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform |
| Synonyms | PP2A B subunit isoform B'-beta, PP2A B subunit isoform B56-beta, PP2A B subunit isoform PR61-beta, PP2A B subunit isoform R5-beta |
| Primary ID | Q15173 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PPP2R5B | up-regulates 
dephosphorylation
|
CASP3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PPP2R5B | down-regulates 
dephosphorylation
|
BCL2 | 0.305 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PPP2R5B | up-regulates activity
dephosphorylation
|
KIF20A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PPP2R5B | down-regulates
dephosphorylation
|
AKT | 0.647 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PPP2R5B | down-regulates
dephosphorylation
|
AKT1 | 0.647 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KLHL15 | down-regulates quantity by destabilization
binding
|
PPP2R5B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Cullin 3-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
PPP2R5B | 0.371 |
| Publications: | 1 | Organism: | Homo Sapiens | |