3.0
Summary
| Name |  SYNGAP1View Modifications |
| Full Name | Ras/Rap GTPase-activating protein SynGAP |
| Synonyms | Neuronal RasGAP, Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1 | KIAA1938 |
| Primary ID | Q96PV0 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Pathways | Glutamatergic synapse |
| Function | Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CAMK2A | up-regulates activity 
phosphorylation
|
SYNGAP1 | 0.439 |
| Publications: | 5 | Organism: | In Vitro | |
| Pathways: | Glutamatergic synapse | |||
| + | SYNGAP1 | up-regulates activity
binding
|
DLG4 | 0.615 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glutamatergic synapse | |||