3.0
Summary
| Name |  SETDB2View Modifications |
| Full Name | Histone-lysine N-methyltransferase SETDB2 |
| Synonyms | Chronic lymphocytic leukemia deletion region gene 8 protein, Lysine N-methyltransferase 1F, SET domain bifurcated 2 | C13orf4, CLLD8, KMT1F |
| Primary ID | Q96T68 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SETDB2 | up-regulates activity 
methylation
|
H3C1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SETDB2 | up-regulates activity
methylation
|
H3-4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SETDB2 | up-regulates activity
methylation
|
H3-3A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SETDB2 | up-regulates activity
methylation
|
Histone H3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |