+ |
EGFR | up-regulates activity
phosphorylation
|
NIBAN2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273637 |
Tyr593 |
PIDWGEEySNSGGGG |
Homo sapiens |
U-251MG Cell |
pmid |
sentence |
26721396 |
We demonstrate here that activated EGFR phosphorylates the Y593 residue of the protein known as family with sequence similarity 129, member B (FAM129B), which is overexpressed in many types of human cancer. FAM129B phosphorylation increased the interaction between FAM129B and Ras, resulting in reduced binding of p120-RasGAP to Ras. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NIBAN2 | up-regulates activity
binding
|
HRAS |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273659 |
|
|
Homo sapiens |
U-251MG Cell |
pmid |
sentence |
26721396 |
EGFR phosphorylates FAM129B, resulting in binding of phosphorylated FAM129B to H-Ras and reduced the association of p120-RasGAP with H-Ras, thereby enhancing H-Ras activation for ERK1/2-dependent β-catenin transactivation for enhanced Warburg effect, tumor cell proliferation, and brain tumorigenesis. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |