Relation Results

Summary

Name TCF12
Full Name Transcription factor 12
Synonyms TCF-12, Class B basic helix-loop-helix protein 20, bHLHb20, DNA-binding protein HTF4, E-box-binding protein, Transcription factor HTF-4 | BHLHB20, HEB, HTF4
Primary ID Q99081
Links - -
Type protein
Relations 7
Function Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

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Type: Score: Layout: SPV 
0.5890.470.670.3690.2580.3280.556ID1TCF12ID3MYOD/HEBNOTCH1NOTCH3PTCRAID2

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Relations
Regulator
Mechanism
target
score ℹ
+ ID1down-regulates activity img/direct_inhibition.png binding TCF12 0.589
Identifier Residue Sequence Organism Cell Line
SIGNOR-241104 Mus musculus C3H10T1/2 Cell
pmid sentence
All three Ids bound with high affinity to E proteins .Each Id was able to disrupt the ability of E protein-MyoD complexes to transactivate from a muscle creatine kinase reporter construct in vivo.
Publications: 1 Organism: Mus Musculus
+ ID3down-regulates activity img/direct_inhibition.png binding TCF12 0.47
Identifier Residue Sequence Organism Cell Line
SIGNOR-241152 Mus musculus C3H10T1/2 Cell
pmid sentence
All three Ids bound with high affinity to E proteins .Each Id was able to disrupt the ability of E protein-MyoD complexes to transactivate from a muscle creatine kinase reporter construct in vivo.
Publications: 1 Organism: Mus Musculus
+ TCF12form complex img/form-complex.png binding MYOD/HEB 0.67
Identifier Residue Sequence Organism Cell Line
SIGNOR-241119 Homo sapiens
pmid sentence
The MyoD family of basic helix-loop-helix transcription factors function as heterodimers with members of the E-protein family to induce myogenic gene activation.
Publications: 1 Organism: Homo Sapiens
+ NOTCH1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TCF12 0.369
Identifier Residue Sequence Organism Cell Line
SIGNOR-197514 Homo sapiens
pmid sentence
E2a positively regulates notch1 expression, which induces the expression of hebalt, bcl11b, and il7r.
Publications: 1 Organism: Homo Sapiens
+ TCF12up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH3 0.258
Identifier Residue Sequence Organism Cell Line
SIGNOR-197517 Homo sapiens T-lymphocyte
pmid sentence
Hebalt positively regulates t-cell genes, such as pt_ and notch3
Publications: 1 Organism: Homo Sapiens
+ TCF12up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PTCRA 0.328
Identifier Residue Sequence Organism Cell Line
SIGNOR-197520 Homo sapiens
pmid sentence
Hebalt positively regulates t-cell genes, such as pt_ and notch3
Publications: 1 Organism: Homo Sapiens
+ ID2down-regulates activity img/direct_inhibition.png binding TCF12 0.556
Identifier Residue Sequence Organism Cell Line
SIGNOR-241131 Mus musculus C3H10T1/2 Cell
pmid sentence
All three Ids bound with high affinity to E proteins .Each Id was able to disrupt the ability of E protein-MyoD complexes to transactivate from a muscle creatine kinase reporter construct in vivo.
Publications: 1 Organism: Mus Musculus
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