| + |
TCF12 | up-regulates quantity by expression 
transcriptional regulation
|
PTCRA |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197520 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22577461 |
Hebalt positively regulates t-cell genes, such as pt_ and notch3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTCRA | up-regulates activity 
binding
|
ZAP70 |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134325 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 1717999 |
Stimulation of the T-cell antigen receptor (TCR) leads to tyrosine phosphorylation of a number of cellular proteins, including phospholipase C (PLC) gamma 1 and the TCR zeta chain. We describe here a 70-kDa tyrosine phosphoprotein (ZAP-70) that associates with zeta within 15 sec following TCR stimulation. The phosphorylation of ZAP-70 and its association with zeta is independent of the other TCR chains |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
PTCRA | up-regulates activity
binding
|
LCK |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166658 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
However, non-canonical mechanisms of p38alfa activation have been also described. One is apparently specific to antigen receptor stimulated t-lymphocytes. This involves phosphorylation of p38alfa on tyr323 by the tcr-proximal tyrosine kinase zap70 and p56lck. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
3.0
PTCRA
- 
- 