Summary

Name NDN
Full Name Necdin
Synonyms NECD_HUMAN
Primary ID Q99608
Links - -
Type protein
Relations 9
Function Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding EID1 0.386
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png NDN 0.256
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png NDN 0.242
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding E2F1 0.579
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYC 0.27
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png binding PIAS1 0.301
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png BMI1 0.256
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png CDKN2A 0.284
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding PPARGC1A 0.331
Publications: 1 Organism: Homo Sapiens