Summary

Name BMI1
Full Name Polycomb complex protein BMI-1
Synonyms Polycomb group RING finger protein 4, RING finger protein 51 | PCGF4, RNF51
Primary ID P35226
Links - -
Type protein
Relations 17
Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation BMI1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BMI1 0.3
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation BMI1 0.455
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation BMI1 0.262
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation BMI1 0.7
Publications: 1
+ up-regulates activity img/direct-activation.png ubiquitination BMI1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png NDN 0.256
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Polycomb repressive complex 1 0.785
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTEN 0.572
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN2A 0.476
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png BMI1 0.256
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN2A 0.476
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDKN2A 0.476
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BMI1 0.487
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BMI1 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation BMI1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling
+ up-regulates activity img/direct-activation.png ubiquitination BMI1 0.354
Publications: 1 Organism: Homo Sapiens