| + |
TAOK2 | up-regulates activity 
phosphorylation, binding
|
MAP2K6 |
0.633 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106465 |
Ser207 |
ISGYLVDsVAKTIDA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11279118 |
Suggesting that tao2 selectively activates mek3 and mek6 of the p38 pathway in intact cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70950 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10497253 |
Cotransfection experiments suggested that tao2 selectively activates mek3 and mek6 but not meks 1, 4, or 7. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAP2K6 | up-regulates activity
phosphorylation
|
STAT4 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251425 |
Ser721 |
PSDLLPMsPSVYAVL |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 10961885 |
MKK6, phosphorylate STAT4 on serine 721. IL-12 induces STAT4 phosphorylation on serine 721 and that mutation of serine 721 interferes with STAT4 transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAP2K6 | up-regulates activity
phosphorylation
|
MAPK13 |
0.645 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273952 |
Thr180 |
RHADAEMtGYVVTRW |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251424 |
Thr180 |
RHADAEMtGYVVTRW |
in vitro |
|
| pmid |
sentence |
| 9218798 |
SKK3 mediates the activation of SAPK4. Phosphorylation and activation of SAPK4 and SAPK2a by purified SKK3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273951 |
Tyr182 |
ADAEMTGyVVTRWYR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10066767 |
p38-δ is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7. we investigated whether this Thr180-Gly-Tyr182 motif was essential for p38-δ activation. Taken together, these results suggest that the dual phosphorylation TGY motif is required for p38-δ activation. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, In Vitro |
| + |
MAP2K6 | up-regulates activity
phosphorylation
|
MAPK14 |
0.733 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40423 |
Thr180 |
RHTDDEMtGYVATRW |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8622669 |
These data indicate that mkk6 phosphorylates p38 map kinase on thr-180 and tyr-182, the sites of phosphorylation that activate p38 map kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40427 |
Tyr182 |
TDDEMTGyVATRWYR |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8622669 |
These data indicate that mkk6 phosphorylates p38 map kinase on thr-180 and tyr-182, the sites of phosphorylation that activate p38 map kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70607 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10480932 |
We have found that p38 mitogen-activated protein kinase, and its direct activator MKK6 are rapidly activated in response to TGF-beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255780 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20551513 |
Expression of a constitutively active mutant of MKK6 (MKK6-glu) (39), but not a kinase-inactive mutant of MKK6 (MKK6-K82A) (39), strongly promoted human MSC differentiation to osteoblasts as shown by increased ALP activity and extracellular matrix mineralization (Figure 4E). Furthermore, MKK6-glu–expressing osteoblasts were treated with inhibitors of p38, JNK, and MEK (Figure 4F). Only treatment with the p38 inhibitor SB203580 blocked the effects of MKK6-glu. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236116 |
|
|
Homo sapiens |
COS-7 Cell |
| pmid |
sentence |
| 8974401 |
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively. |
|
| Publications: |
5 |
Organism: |
Chlorocebus Aethiops, Homo Sapiens |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TGF-beta Signaling, Toll like receptors |
| + |
MAP2K6 | up-regulates
phosphorylation
|
MAPK12 |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184134 |
Thr183 |
RQADSEMtGYVVTRW |
Homo sapiens |
|
| pmid |
sentence |
| 19230643 |
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub of the mitogen-activated protein kinase superfamily . the p38 mapkinasekinasemkk6 is identified as a common activator of p38 alpha, p38 beta 2, and p38 gamma mapkinaseisoforms . p38mapks are activated by dual phosphorylation on a t-x-y motif in the activation loop through the action of map kinase kinases |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184138 |
Tyr185 |
ADSEMTGyVVTRWYR |
Homo sapiens |
|
| pmid |
sentence |
| 19230643 |
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub of the mitogen-activated protein kinase superfamily . the p38 mapkinasekinasemkk6 is identified as a common activator of p38 alpha, p38 beta 2, and p38 gamma mapkinaseisoforms . p38mapks are activated by dual phosphorylation on a t-x-y motif in the activation loop through the action of map kinase kinases |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP3K1 | up-regulates
phosphorylation
|
MAP2K6 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59679 |
Thr211 |
LVDSVAKtIDAGCKP |
Homo sapiens |
|
| pmid |
sentence |
| 9712898 |
Both wild type and kinase-inactive mutant rip immunoprecipitates can active mkk6 in vitrohe sapks are activated by at least two meks, sapk/erk kinase-1 (sek1, also called mapk-kinase (mkk)) and mkk7 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, Toll like receptors |
| + |
MAP2K6 | up-regulates activity
phosphorylation
|
HSF4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275493 |
Thr471 |
LGLPGALtIYSTPES |
|
|
| pmid |
sentence |
| 24361130 |
Regulation of Hsf4b nuclear translocation and transcription activity by phosphorylation at threonine 472| At the upstream, MEK6 was found to interact with Hsf4b and enhance Hsf4b's nuclear translocation and transcription activity, probably by phosphorylation at sites such as T472. Taken together, our results suggest that phosphotylation of Hsf4b at T472 by protein kinases such as MEI |
|
| Publications: |
1 |
| + |
MAP2K6 | up-regulates
phosphorylation
|
PAK6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130975 |
Tyr566 |
KSLVGTPyWMAPEVI |
Homo sapiens |
|
| pmid |
sentence |
| 15550393 |
Moreover, pak6 was directly activated by mkk6, and mutation of tyrosine 566 in a consensus mkk6 site (threonine-proline-tyrosine, tpy) in the activation loop of the pak6 kinase domain prevented activation by mkk6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K6 | up-regulates activity
|
p38 |
0.733 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260721 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 9430721 |
The p38 MAP kinase kinase MKK6 is identified as a common activator of p38 alpha, p38 beta 2, and p38 gamma MAP kinase isoforms |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260720 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10480932 |
P38 mitogen-activated protein kinase, and its direct activator MKK6 are rapidly activated in response to TGF-beta. |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops, Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
MAP3K5 | up-regulates activity
phosphorylation
|
MAP2K6 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45353 |
|
|
Homo sapiens |
COS-7 Cell |
| pmid |
sentence |
| 8974401 |
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis |
| + |
MAP2K6 | up-regulates
phosphorylation
|
MAPK13 |
0.645 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42390 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8663074 |
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub of the mitogen-activated protein kinase superfamily. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105698 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11242034 |
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub of the mitogen-activated protein kinase superfamily. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP2K6 | up-regulates
phosphorylation
|
MAPK11 |
0.688 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-54947 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9430721 |
The p38 mapkinasekinasemkk6 is identified as a common activator of p38 alpha, p38 beta 2, and p38 gamma mapkinaseisoforms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K4 | up-regulates activity
phosphorylation
|
MAP2K6 |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62372 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9841871 |
When truncated mapkkk4 (deltamapkkk4) was overexpressed in hek293 cells, it was constitutively activeco-expressed map kinase kinase (mkk)-1, mkk-4, mkk-3 and mkk-6 were activated in vivo by deltamapkkk4. All of the above mkks purified from escherichia coli were phosphorylated and activated by deltamapkkk4 immunoprecipitates in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-50894 |
|
|
Homo sapiens |
COS-7 Cell |
| pmid |
sentence |
| 9305639 |
These results, therefore, suggest that mtk1 directly phosphorylates and activates mkk3, mkk6 and sek1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP2K6 |
0.753 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109497 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11460167 |
The activity of tak1 to phosphorylate mkk6, which activates the jnk-p38 kinase pathway, is directly regulated by k63-linked polyubiquitination |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236145 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Tak1 can phosphorylate and activate map kinase kinase 3/6 (mkk3/6), and numerous studies have demonstrated a requirement for mkk3/6 activity in the initiation of myoblast differentiation, again in a p38-dependent manner. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling, Toll like receptors |
| + |
MAP2K6 | up-regulates
phosphorylation
|
MAPK9 |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45369 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8974401 |
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K6 | up-regulates
phosphorylation
|
MAPK10 |
0.441 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45363 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8974401 |
A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subgroups of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-activated protein kinase (sapk, also known as jnk;c-jun amino-terminal kinase) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K3 | up-regulates 
|
MAP2K6 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68020 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10347227 |
However, the autocatalytic activities of both mkk6 and mkk7 were enhanced by their coexpression with either mekk3 or mekk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K6 | up-regulates activity
phosphorylation
|
MAP2K6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236122 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10347227 |
However, the autocatalytic activities of both mkk6 and mkk7 were enhanced by their coexpression with either mekk3 or mekk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling, Toll like receptors |
| + |
MAP2K6 | up-regulates
phosphorylation
|
CRK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42384 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8663074 |
Mapkk6 was shown to phosphorylate and specifically activate the p38/mpk2 sub-family of the mitogen-activated protein kinase superfamily. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SAPK/JNK Signaling |
3.0
MAP2K6
- 
- 