Summary

Name MAP2K3
Full Name Dual specificity mitogen-activated protein kinase kinase 3
Synonyms MAP kinase kinase 3, MAPKK 3, MAPK/ERK kinase 3, MEK 3, Stress-activated protein kinase kinase 2, SAPK kinase 2, SAPKK-2, SAPKK2 | MEK3, MKK3, PRKMK3, SKK2
Primary ID P46734
Links - -
Type protein
Relations 20
Pathways COVID-19 Causal Network, FAP: BMP, FAP: TGF beta, Osteoblast: BMP, Osteoblast: TGF beta, P38 Signaling, P38 Signaling and Myogenesis, SARS-CoV MAPK PERTURBATION, TNF-alpha Signaling, TGF-beta Signaling, Toll like receptors
Function Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ MAP3K5up-regulates activity img/direct-activation.png phosphorylation MAP2K3 0.582
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
+ TAOK2up-regulates activity img/direct-activation.png phosphorylation, binding MAP2K3 0.654
Publications: 2 Organism: Homo Sapiens, In Vitro
Pathways:P38 Signaling
+ TAOK1up-regulates activity img/direct-activation.png phosphorylation MAP2K3 0.559
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ MAP3K3up-regulates activity img/direct-activation.png phosphorylation MAP2K3 0.538
Publications: 1 Organism: Homo Sapiens
+ MAP2K3up-regulates activity img/direct-activation.png phosphorylation MAPK13 0.59
Publications: 2 Organism: Homo Sapiens
+ MAP2K3up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.715
Publications: 5 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling, TGF-beta Signaling, Toll like receptors
+ MAP2K3up-regulates img/direct-activation.png phosphorylation DYRK1B 0.355
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ MAP2K3up-regulates activity img/direct-activation.png phosphorylation p38 0.715
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ MAP3K7up-regulates activity img/direct-activation.png phosphorylation MAP2K3 0.483
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling, Toll like receptors
+ MAP2K3up-regulates img/direct-activation.png phosphorylation MAPK12 0.632
Publications: 1 Organism: Homo Sapiens
+ MAP3K11up-regulates activity img/direct-activation.png phosphorylation MAP2K3 0.47
Publications: 1 Organism: Homo Sapiens
+ MAP3K4up-regulates activity img/direct-activation.png phosphorylation MAP2K3 0.627
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling