Summary

Name BAG1
Full Name BAG family molecular chaperone regulator 1
Synonyms BAG-1, Bcl-2-associated athanogene 1 | HAP
Primary ID Q99933
Links - -
Type protein
Relations 8
Function Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation BAG1 0.287
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAG1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding HSPA8 0.89
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png PPP1R15A 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BCL2 0.425
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding HSPA8 0.89
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAG1 0.336
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding STUB1 0.561
Publications: 1 Organism: Chlorocebus Aethiops