Summary

Name WDR83
Full Name WD repeat domain-containing protein 83
Synonyms Mitogen-activated protein kinase organizer 1, MAPK organizer 1 | MORG1
Primary ID Q9BRX9
Links - -
Type protein
Relations 4
Function Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.

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Relations

Regulator Mechanism target score ℹ
+ WDR83up-regulates img/direct-activation.png binding RAF1 0.526
Publications: 1 Organism: Homo Sapiens
+ WDR83up-regulates img/direct-activation.png binding MEK1/2 0.534
Publications: 1 Organism: Homo Sapiens
+ WDR83up-regulates img/direct-activation.png binding MAP2K1 0.527
Publications: 1 Organism: Homo Sapiens
+ WDR83up-regulates img/direct-activation.png binding MAPK3 0.509
Publications: 1 Organism: Homo Sapiens