3.0
Summary
| Name |  TINF2View Modifications |
| Full Name | TERF1-interacting nuclear factor 2 |
| Synonyms | TRF1-interacting nuclear protein 2 | TIN2 |
| Primary ID | Q9BSI4 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RPS6KA3 |
phosphorylation
|
TINF2 | 0.351 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | SP1 | up-regulates quantity by expression 
transcriptional regulation
|
TINF2 | 0.2 |
| Publications: | 1 | |||
| + | TINF2 | form complex 
binding
|
Shelterin complex | 0.883 |
| Publications: | 1 | Organism: | Homo Sapiens | |