3.0
Summary
| Name |  DUSP26View Modifications |
| Full Name | Dual specificity protein phosphatase 26 |
| Synonyms | Dual specificity phosphatase SKRP3, Low-molecular-mass dual-specificity phosphatase 4, DSP-4, LDP-4, Mitogen-activated protein kinase phosphatase 8, MAP kinase phosphatase 8, MKP-8, Novel amplified gene in thyroid anaplastic cancer | DUSP24, LDP4, MKP8, NATA1, SKRP3 |
| Primary ID | Q9BV47 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Inhibitors | 8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid |
| Function | Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | DUSP26 | down-regulates activity 
dephosphorylation
|
FADD | 0.38 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DUSP26 | down-regulates activity
dephosphorylation
|
TP53 | 0.374 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | DUSP26 | down-regulates
dephosphorylation
|
TP53 | 0.374 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | 8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid | down-regulates activity
chemical inhibition
|
DUSP26 | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |