Relation Results

Summary

Name	FADD View Modifications
Full Name	FAS-associated death domain protein
Synonyms	FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD \| MORT1
Primary ID	Q13158
Links	- -
Type	protein
Relations	17
Pathways	Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS, TNF-alpha Signaling
Function	Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

Viewer

Search Tools

Refine search:

by mechanism

by effect

by organism:

by tissue:

by cell-line

▶Modifications Tables

Relations

Regulator

Mechanism

target

score ℹ

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.504

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, TNF-alpha Signaling

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.459

Publications:

1

Organism:

Homo Sapiens

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

dephosphorylation

0.366

Publications:

1

Organism:

Homo Sapiens

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.498

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, TNF-alpha Signaling

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.332

Publications:

1

Organism:

Homo Sapiens

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.436

Publications:

1

Organism:

In Vitro

up-regulates img/direct-activation.png

img/direct-activation.png

phosphorylation

0.343

Publications:

1

Organism:

Homo Sapiens

up-regulates activity img/direct-activation.png

img/direct-activation.png

binding

0.931

Publications:

1

Organism:

Homo Sapiens

Pathways:

Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS, TNF-alpha Signaling

up-regulates activity img/direct-activation.png

img/direct-activation.png

binding

0.791

Publications:

2

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, TNF-alpha Signaling

up-regulates activity img/direct-activation.png

img/direct-activation.png

binding

0.782

Publications:

2

Organism:

Homo Sapiens

Pathways:

Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS, TNF-alpha Signaling

up-regulates activity img/direct-activation.png

img/direct-activation.png

binding

0.91

Publications:

1

Organism:

Homo Sapiens

Pathways:

COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS

up-regulates img/direct-activation.png

img/direct-activation.png

binding

0.794

Publications:

1

Organism:

Homo Sapiens

up-regulates img/direct-activation.png

img/direct-activation.png

binding

0.849

Publications:

1

Organism:

Homo Sapiens

up-regulates quantity by expression img/indirect-activation.png

img/indirect-activation.png

transcriptional regulation

0.2

Publications:

1

Organism:

Homo Sapiens

up-regulates img/direct-activation.png

img/direct-activation.png

binding

0.831

Publications:

1

Organism:

Homo Sapiens