4.0
Summary
| Name |  FADDView Modifications |
| Full Name | FAS-associated death domain protein |
| Synonyms | FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD | MORT1 |
| Primary ID | Q13158 |
| Links |  -  -  |
| Type | protein |
| Relations | 17 |
| Pathways | Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS, TNF-alpha Signaling |
| Function | Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAP2K7 | down-regulates activity 
phosphorylation
|
FADD | 0.5 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, TNF-alpha Signaling | |||
| + | HIPK3 | down-regulates activity
phosphorylation
|
FADD | 0.435 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PLK1 | down-regulates activity
phosphorylation
|
FADD | 0.458 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DUSP26 | down-regulates activity
dephosphorylation
|
FADD | 0.368 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK1A1 | down-regulates activity
phosphorylation
|
FADD | 0.331 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAP3K1 | down-regulates activity
phosphorylation
|
FADD | 0.506 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, TNF-alpha Signaling | |||
| + | AURKA | up-regulates 
phosphorylation
|
FADD | 0.344 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TNFRSF10B | up-regulates
binding
|
FADD | 0.85 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FADD | up-regulates activity
binding
|
CASP8 | 0.931 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS, TNF-alpha Signaling | |||
| + | TRADD | up-regulates activity
binding
|
FADD | 0.784 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS, TNF-alpha Signaling | |||
| + | RUNX3 | up-regulates quantity by expression 
transcriptional regulation
|
FADD | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FADD | up-regulates activity
binding
|
RIPK1 | 0.793 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, TNF-alpha Signaling | |||
| + | TNFRSF10A | up-regulates
binding
|
FADD | 0.832 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FAS | up-regulates activity
binding
|
FADD | 0.91 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, SARS-COV APOPTOSIS | |||
| + | FADD | up-regulates
binding
|
CASP10 | 0.796 |
| Publications: | 1 | Organism: | Homo Sapiens | |